SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1lyw CATHEPSIN D
(Homo
sapiens) 		4 / 8 TYR B 139
THR B 201
TRP B 206
LEU B 198
 None
 1.37A 1uw6A-1lywB:
undetectable
1uw6B-1lywB:
undetectable		 1uw6A-1lywB:
21.74
1uw6B-1lywB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1lyw CATHEPSIN D
(Homo
sapiens) 		4 / 6 PHE B 325
TYR B 283
VAL B 208
PHE B 342
 None
 1.01A 3ltwA-1lywB:
undetectable		 3ltwA-1lywB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1lyw CATHEPSIN D
(Homo
sapiens) 		3 / 3 TYR B 330
THR B 186
GLU B 180
 None
 0.82A 4df3A-1lywB:
undetectable		 4df3A-1lywB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1lyw CATHEPSIN D
(Homo
sapiens) 		3 / 3 TYR B 330
THR B 186
GLU B 180
 None
 0.82A 4df3B-1lywB:
undetectable		 4df3B-1lywB:
21.30