SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1lzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  87
GLY A  88
GLY A  89
SER A 160
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-4.1A)
 0.79A 1dx6A-1lzkA:
19.0		 1dx6A-1lzkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  87
GLY A  88
GLY A  89
SER A 160
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-4.1A)
 0.84A 1qtiA-1lzkA:
18.1		 1qtiA-1lzkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 8 GLY A 168
GLY A 164
GLY A 163
LEU A 165
 None
 0.66A 1qzzA-1lzkA:
3.3		 1qzzA-1lzkA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 11 LEU A  54
ALA A 136
ILE A  85
ILE A 154
ILE A  67
 None
 0.99A 1sduA-1lzkA:
0.0		 1sduA-1lzkA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  87
GLY A  88
GLY A  89
SER A 160
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-4.1A)
 0.81A 1w6rA-1lzkA:
19.0		 1w6rA-1lzkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  88
GLY A  89
SER A 160
LEU A 208
HIS A 290
 CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
None
CAC  A 500 (-4.1A)
 0.94A 1ya4C-1lzkA:
18.7		 1ya4C-1lzkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 8 GLY A  87
GLY A  88
GLY A  89
ALA A 161
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.2A)
CAC  A 500 (-4.1A)
 0.35A 1yajC-1lzkA:
18.6		 1yajC-1lzkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 6 LEU A 254
LEU A 282
LEU A 274
LEU A 246
 None
 1.00A 2ab2A-1lzkA:
undetectable		 2ab2A-1lzkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 8 GLY A  88
GLY A  89
ALA A 161
HIS A 290
 CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.2A)
CAC  A 500 (-4.1A)
 0.35A 2ha4A-1lzkA:
18.8		 2ha4A-1lzkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 7 GLY A  88
GLY A  89
ALA A 161
HIS A 290
 CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.2A)
CAC  A 500 (-4.1A)
 0.29A 2ha4B-1lzkA:
19.3		 2ha4B-1lzkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 SER A 235
ASP A 132
GLY A 128
PHE A 126
ALA A 136
 None
 1.30A 2kceA-1lzkA:
undetectable		 2kceA-1lzkA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 SER A 235
ASP A 132
GLY A 128
PHE A 126
ALA A 136
 None
 1.21A 2kceB-1lzkA:
0.0		 2kceB-1lzkA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 PHE A  23
ALA A 214
ALA A  31
THR A  94
LEU A 120
 None
 1.06A 2x2nB-1lzkA:
undetectable		 2x2nB-1lzkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLN A 184
GLY A 158
GLY A 163
LEU A  82
TYR A 253
 None
 1.25A 2zw9A-1lzkA:
3.6		 2zw9A-1lzkA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A 163
GLY A 291
LEU A 186
THR A 256
THR A 288
 None
 1.18A 3eeyF-1lzkA:
undetectable		 3eeyF-1lzkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 7 ALA A 114
VAL A  65
VAL A 116
LEU A  83
 None
 0.85A 3o14A-1lzkA:
undetectable		 3o14A-1lzkA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 11 ASP A 132
PHE A  90
GLY A  89
SER A 217
GLY A 128
 None
None
CAC  A 500 (-3.5A)
None
None
 1.41A 3v3oC-1lzkA:
1.2		 3v3oC-1lzkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 5 TRP A 218
GLY A 163
ALA A 161
PHE A 126
 None
None
CAC  A 500 (-3.2A)
None
 1.47A 3wqwA-1lzkA:
0.6		 3wqwA-1lzkA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 5 ARG A 107
VAL A  70
LEU A  51
SER A  50
 None
 1.13A 4e1gA-1lzkA:
undetectable		 4e1gA-1lzkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  87
GLY A  88
GLY A  89
SER A 160
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-4.1A)
 0.78A 4ey6A-1lzkA:
19.1		 4ey6A-1lzkA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 GLY A  87
GLY A  88
GLY A  89
SER A 160
HIS A 290
 CAC  A 500 ( 3.8A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-4.1A)
 0.80A 4ey6B-1lzkA:
17.9		 4ey6B-1lzkA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		3 / 3 ASP A  34
TRP A 209
SER A  97
 None
CAC  A 500 (-3.2A)
None
 0.88A 4lrhA-1lzkA:
0.0		 4lrhA-1lzkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 9 ALA A 296
SER A 255
ILE A 188
GLY A 304
ALA A 305
 None
 1.15A 4r1zA-1lzkA:
undetectable		 4r1zA-1lzkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.01A 4rrwA-1lzkA:
0.0		 4rrwA-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.03A 4rrwB-1lzkA:
undetectable		 4rrwB-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.03A 4rrwC-1lzkA:
0.0		 4rrwC-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.01A 4rrzA-1lzkA:
0.0		 4rrzA-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.03A 4rrzB-1lzkA:
undetectable		 4rrzB-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.03A 4rrzC-1lzkA:
0.0		 4rrzC-1lzkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 5 ILE A  67
VAL A 116
PHE A 185
HIS A 143
 None
 1.27A 4rzvA-1lzkA:
0.0		 4rzvA-1lzkA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 6 CYH A 102
GLU A 187
GLY A 158
GLY A 157
 None
 0.95A 5a06D-1lzkA:
3.4		 5a06D-1lzkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 6 SER A  98
PRO A 100
PHE A 101
GLU A 104
 None
 1.18A 5b8iA-1lzkA:
undetectable		 5b8iA-1lzkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		3 / 3 PRO A 180
LEU A  83
SER A 152
 None
 0.84A 5fsaB-1lzkA:
0.0		 5fsaB-1lzkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 6 PRO A 240
ARG A 272
THR A 244
ILE A 236
 None
 1.46A 5ih0A-1lzkA:
undetectable		 5ih0A-1lzkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.13A 5ikqB-1lzkA:
undetectable		 5ikqB-1lzkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 12 LEU A 249
VAL A 170
GLY A 168
ALA A 167
LEU A 191
 None
 1.02A 5ikrA-1lzkA:
0.0		 5ikrA-1lzkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 8 THR A   6
SER A 284
ASP A 264
SER A 199
 None
 0.95A 5l5fY-1lzkA:
0.0
5l5fZ-1lzkA:
0.0		 5l5fY-1lzkA:
22.26
5l5fZ-1lzkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		5 / 10 VAL A 170
ALA A 166
THR A 256
PRO A 240
LEU A 191
 None
 1.18A 5mm4B-1lzkA:
3.4		 5mm4B-1lzkA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		4 / 6 PHE A 285
PRO A 286
GLY A 287
THR A 288
 None
 0.88A 5x24A-1lzkA:
0.0		 5x24A-1lzkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1lzk HEROIN ESTERASE
(Rhodococcus
sp.) 		3 / 3 LEU A 109
ASP A 150
ILE A 154
 None
 0.61A 6dh0B-1lzkA:
undetectable		 6dh0B-1lzkA:
13.89