SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 7 ARG A  79
THR A 247
VAL A 249
ALA A  61
 None
 1.07A 1fo4B-1m0uA:
undetectable		 1fo4B-1m0uA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		3 / 3 PHE A  68
LEU A 100
MET A  97
 None
 0.63A 1mx1D-1m0uA:
undetectable		 1mx1D-1m0uA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
TRP A  85
TYR A 153
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
GSH  A 500 (-3.6A)
None
 0.85A 2gssA-1m0uA:
23.1		 2gssA-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.43A 2gssA-1m0uA:
23.1		 2gssA-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
TRP A  85
TYR A 153
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
GSH  A 500 (-3.6A)
None
 0.85A 2gssB-1m0uA:
23.1		 2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.43A 2gssB-1m0uA:
23.1		 2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 8 LEU A 179
ALA A 198
GLY A 204
ILE A 205
LEU A 224
 None
 1.16A 2o4nB-1m0uA:
undetectable		 2o4nB-1m0uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 6 LEU A 179
VAL A 183
LYS A 184
ILE A 141
 None
 0.76A 2piwA-1m0uA:
undetectable		 2piwA-1m0uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 10 VAL A 231
PHE A 202
ASN A 186
VAL A 183
GLY A 188
 None
 1.38A 2x2iD-1m0uA:
undetectable		 2x2iD-1m0uA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 VAL A 227
VAL A 228
THR A 196
ARG A 225
 None
 1.08A 3bjwA-1m0uA:
0.0		 3bjwA-1m0uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 VAL A 227
VAL A 228
THR A 196
ARG A 225
 None
 1.07A 3bjwC-1m0uA:
1.4		 3bjwC-1m0uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 4 LEU A  64
PRO A  63
LEU A  67
ARG A 115
 None
 1.43A 3hcoA-1m0uA:
undetectable		 3hcoA-1m0uA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.49A 3hjoA-1m0uA:
23.0		 3hjoA-1m0uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 7 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.49A 3kmoB-1m0uA:
22.8		 3kmoB-1m0uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.40A 3n9jA-1m0uA:
23.1		 3n9jA-1m0uA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 PRO A  98
LEU A  52
TYR A  54
PRO A 245
TYR A  75
 GSH  A 500 ( 4.5A)
None
GSH  A 500 (-4.7A)
None
None
 1.35A 3qlhA-1m0uA:
0.0		 3qlhA-1m0uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 PRO A  63
ILE A 205
TRP A 197
ILE A 111
 None
 0.90A 3sfeB-1m0uA:
undetectable
3sfeC-1m0uA:
2.0		 3sfeB-1m0uA:
18.55
3sfeC-1m0uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 7 GLY A 125
TRP A 197
ALA A 198
ASP A 199
 None
 0.83A 3ur0B-1m0uA:
0.0		 3ur0B-1m0uA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 LEU A  67
ALA A 203
VAL A 138
ILE A 141
 None
 0.73A 4xe3A-1m0uA:
undetectable		 4xe3A-1m0uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 LEU A  67
ALA A 203
VAL A 138
ILE A 141
 None
 0.84A 4xe3B-1m0uA:
undetectable		 4xe3B-1m0uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.07A 5n0oA-1m0uA:
undetectable		 5n0oA-1m0uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.08A 5n0rA-1m0uA:
undetectable		 5n0rA-1m0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.11A 5n0sA-1m0uA:
undetectable		 5n0sA-1m0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.08A 5n0wA-1m0uA:
undetectable		 5n0wA-1m0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.08A 5n0wB-1m0uA:
undetectable		 5n0wB-1m0uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 ILE A 205
GLY A 204
VAL A 228
VAL A 231
VAL A 138
 None
 1.06A 5n4iA-1m0uA:
undetectable		 5n4iA-1m0uA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 LEU A  64
PHE A  68
LEU A 117
PHE A 116
 None
 1.03A 5x19C-1m0uA:
3.6
5x19J-1m0uA:
0.0		 5x19C-1m0uA:
21.20
5x19J-1m0uA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 TYR A 201
VAL A 200
LEU A  67
SER A 110
 None
None
None
GSH  A 500 (-2.5A)
 1.23A 6a7pA-1m0uA:
3.1		 6a7pA-1m0uA:
19.45