SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 490
TYR A 491
LEU A 443
LEU A 466
ASP A 486
 None
 1.43A 1e7wA-1m0wA:
undetectable		 1e7wA-1m0wA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 152
SER A 462
LEU A 195
ILE A 445
SER A 158
 3GC  A 501 (-4.2A)
None
None
None
None
 1.05A 1eqgB-1m0wA:
undetectable		 1eqgB-1m0wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 107
SER A 106
TYR A 108
LEU A 316
 None
 1.29A 1xz1A-1m0wA:
undetectable		 1xz1A-1m0wA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 107
SER A 106
TYR A 108
LEU A 316
 None
 1.29A 1xz3A-1m0wA:
undetectable		 1xz3A-1m0wA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 336
GLY A 337
LYS A 346
LEU A 350
 None
 0.88A 1ya4A-1m0wA:
undetectable		 1ya4A-1m0wA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 319
LEU A 104
TYR A 293
TYR A 284
 None
 1.14A 1yc2B-1m0wA:
0.1
1yc2C-1m0wA:
1.4		 1yc2B-1m0wA:
19.58
1yc2C-1m0wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A  18
ASN A  19
VAL A  46
ILE A  48
 None
 0.65A 1z2bC-1m0wA:
undetectable		 1z2bC-1m0wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
THR A 286
VAL A 224
 None
 0.92A 2q64A-1m0wA:
undetectable		 2q64A-1m0wA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 447
TYR A 446
GLY A 125
LEU A 124
ILE A 126
 None
 1.13A 2y7kD-1m0wA:
undetectable		 2y7kD-1m0wA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 155
ARG A 128
ILE A 445
GLY A 463
SER A 189
 None
3GC  A 501 (-2.8A)
None
None
None
 1.44A 3bpxA-1m0wA:
0.0
3bpxB-1m0wA:
0.1		 3bpxA-1m0wA:
15.26
3bpxB-1m0wA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 230
ASP A 233
SER A 441
ASP A 486
TYR A 446
 3GC  A 501 (-3.8A)
None
None
None
None
 1.43A 3havC-1m0wA:
0.4		 3havC-1m0wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 126
PRO A 314
GLY A 125
SER A 321
 None
 0.92A 3lslA-1m0wA:
0.0
3lslD-1m0wA:
0.0		 3lslA-1m0wA:
21.43
3lslD-1m0wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 321
ILE A 126
PRO A 314
GLY A 125
 None
 0.93A 3lslA-1m0wA:
undetectable
3lslD-1m0wA:
0.0		 3lslA-1m0wA:
21.43
3lslD-1m0wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 446
GLY A 444
ASP A 130
 None
 0.69A 3ou6C-1m0wA:
undetectable		 3ou6C-1m0wA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 465
GLY A 444
LEU A 443
GLU A 442
 None
None
None
ANP  A 504 (-2.8A)
 0.85A 3tgvB-1m0wA:
undetectable		 3tgvB-1m0wA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 285
LEU A 237
GLU A 238
 3GC  A 501 (-3.8A)
None
None
 0.71A 4l3gF-1m0wA:
0.0		 4l3gF-1m0wA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  18
ASN A  19
VAL A  46
ILE A  48
 None
 0.65A 5bmvC-1m0wA:
undetectable		 5bmvC-1m0wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  72
TYR A 131
GLN A 144
 None
 1.02A 5jsdA-1m0wA:
0.0
5jsdB-1m0wA:
0.0		 5jsdA-1m0wA:
21.64
5jsdB-1m0wA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  72
TYR A 131
GLN A 144
 None
 1.02A 5jsdB-1m0wA:
0.0
5jsdC-1m0wA:
0.0		 5jsdB-1m0wA:
21.64
5jsdC-1m0wA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 336
LYS A 345
LEU A  71
GLU A  70
 None
 1.31A 5weaA-1m0wA:
undetectable		 5weaA-1m0wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 414
GLN A 384
LEU A 364
GLY A 365
GLY A 368
 None
 0.92A 5wyqB-1m0wA:
undetectable		 5wyqB-1m0wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1m0w GLUTATHIONE
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 142
THR A 352
GLN A 141
GLU A 416
 None
 1.03A 6c06C-1m0wA:
undetectable		 6c06C-1m0wA:
undetectable