SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		5 / 11 SER A 114
ASP A 101
ASN A 102
THR A 108
GLY A 109
 None
 1.41A 2hmaA-1m1lA:
0.4		 2hmaA-1m1lA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		4 / 7 LEU A 120
LEU A  95
PHE A 118
LEU A 179
 None
 0.93A 2vq5B-1m1lA:
undetectable		 2vq5B-1m1lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		4 / 4 LEU A 234
GLN A 217
THR A 180
THR A 225
 None
 1.44A 2zj0D-1m1lA:
undetectable		 2zj0D-1m1lA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		5 / 9 LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.42A 4c9kB-1m1lA:
undetectable		 4c9kB-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		6 / 12 ILE A  91
LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.43A 4c9lA-1m1lA:
undetectable		 4c9lA-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		6 / 12 ILE A  91
LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.44A 4c9lB-1m1lA:
undetectable		 4c9lB-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		6 / 12 ILE A  91
LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.41A 4c9oA-1m1lA:
0.0		 4c9oA-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		6 / 12 ILE A  91
LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
 None
 1.38A 4c9oB-1m1lA:
0.0		 4c9oB-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		5 / 11 LEU A 120
LEU A  98
MET A 141
GLN A 142
ALA A 145
 None
 1.43A 4hwkB-1m1lA:
0.0		 4hwkB-1m1lA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		5 / 12 MET A 177
GLY A 158
GLN A 217
ARG A 224
PHE A 155
 None
 1.48A 4p6xK-1m1lA:
undetectable		 4p6xK-1m1lA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		3 / 3 ASP A 159
GLU A 181
SER A 151
 None
 0.75A 5bw4B-1m1lA:
undetectable		 5bw4B-1m1lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		4 / 5 PRO A 134
HIS A  89
LEU A 144
PHE A  93
 None
 1.35A 5igjA-1m1lA:
undetectable		 5igjA-1m1lA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1m1l SUPPRESSOR OF FUSED
(Homo
sapiens) 		3 / 3 GLU A 207
HIS A 176
VAL A 203
 None
 0.83A 5trqB-1m1lA:
0.0		 5trqB-1m1lA:
21.26