SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 VAL A 229
VAL A 262
TRP A 264
 None
 0.95A 1av2A-1m2wA:
undetectable
1av2B-1m2wA:
undetectable		 1av2A-1m2wA:
2.87
1av2B-1m2wA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 116
VAL A  63
ALA A  30
ILE A  32
ILE A 131
 None
None
None
None
NAD  A5500 (-3.9A)
 0.93A 1epbB-1m2wA:
0.0		 1epbB-1m2wA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 CYH A 170
ALA A 172
GLN A 175
ALA A 120
HIS A 215
 None
 1.03A 1fbyA-1m2wA:
undetectable		 1fbyA-1m2wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 CYH A 170
ALA A 172
GLN A 175
ALA A 120
HIS A 215
 None
 1.03A 1fbyB-1m2wA:
undetectable		 1fbyB-1m2wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 PHE A 166
THR A 199
VAL A 198
ALA A 205
 None
 0.87A 1fo4B-1m2wA:
undetectable		 1fo4B-1m2wA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 LEU A 115
ALA A 120
PHE A 168
PHE A 166
ILE A 169
 None
 1.26A 1g5yC-1m2wA:
undetectable		 1g5yC-1m2wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 203
ILE A 169
ILE A 124
LEU A 119
HIS A  31
 None
 1.26A 1kyvA-1m2wA:
2.6
1kyvE-1m2wA:
2.7		 1kyvA-1m2wA:
16.33
1kyvE-1m2wA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 124
LEU A 119
HIS A  31
LEU A 203
ILE A 169
 None
 1.23A 1kyvB-1m2wA:
2.9
1kyvC-1m2wA:
3.0		 1kyvB-1m2wA:
16.33
1kyvC-1m2wA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ILE A 124
LEU A 119
HIS A  31
LEU A 203
ILE A 169
 None
 1.22A 1kyvC-1m2wA:
3.0
1kyvD-1m2wA:
2.8		 1kyvC-1m2wA:
16.33
1kyvD-1m2wA:
16.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_A_MTLA5600_0
(MANNITOL
DEHYDROGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		9 / 9 ASN A 191
ASP A 230
LYS A 295
LEU A 299
ASN A 300
HIS A 303
ARG A 373
VAL A 374
LYS A 381
 NAD  A5500 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.8A)
MTL  A5600 ( 4.7A)
MTL  A5600 (-3.2A)
MTL  A5600 (-3.8A)
MTL  A5600 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.9A)
 0.04A 1m2wA-1m2wA:
67.1		 1m2wA-1m2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_B_MTLB6600_0
(MANNITOL
DEHYDROGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		9 / 9 ASN A 191
ASP A 230
LYS A 295
LEU A 299
ASN A 300
HIS A 303
ARG A 373
VAL A 374
LYS A 381
 NAD  A5500 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.8A)
MTL  A5600 ( 4.7A)
MTL  A5600 (-3.2A)
MTL  A5600 (-3.8A)
MTL  A5600 ( 3.1A)
MTL  A5600 (-3.6A)
MTL  A5600 (-2.9A)
 0.08A 1m2wB-1m2wA:
64.9		 1m2wB-1m2wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
 MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
 1.16A 1t6zA-1m2wA:
1.5		 1t6zA-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 11 VAL A 374
VAL A 318
ARG A 373
ILE A 232
ASP A 369
 MTL  A5600 (-3.6A)
None
MTL  A5600 ( 3.1A)
MTL  A5600 (-4.5A)
None
 1.19A 1t6zB-1m2wA:
1.2		 1t6zB-1m2wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 ALA A 305
VAL A 407
TRP A 410
 None
 0.98A 1tkqA-1m2wA:
undetectable		 1tkqA-1m2wA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 THR A 174
GLU A 213
HIS A 221
 None
 0.92A 1xwfC-1m2wA:
4.7		 1xwfC-1m2wA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 LEU A 437
VAL A 438
GLY A 436
ASP A 428
ILE A 426
 None
 1.34A 2a1oB-1m2wA:
0.0		 2a1oB-1m2wA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A  39
VAL A  96
GLY A 249
 None
 0.63A 2avvE-1m2wA:
undetectable		 2avvE-1m2wA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 1.02A 2g70A-1m2wA:
3.0		 2g70A-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 0.93A 2g70B-1m2wA:
3.1		 2g70B-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 0.98A 2g72A-1m2wA:
3.3		 2g72A-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 TYR A  86
GLY A  89
ASP A  90
ASN A 364
 None
 1.01A 2g72B-1m2wA:
3.3		 2g72B-1m2wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 THR A  25
GLN A  27
SER A  59
TYR A  81
 None
 1.35A 2xz5A-1m2wA:
0.0
2xz5C-1m2wA:
0.0		 2xz5A-1m2wA:
18.44
2xz5C-1m2wA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 203
ALA A  30
VAL A  63
ILE A 218
THR A 174
 None
 1.04A 3czhB-1m2wA:
0.0		 3czhB-1m2wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 SER A 101
ASP A 104
ASP A 252
TRP A 254
 None
 1.12A 3havA-1m2wA:
2.1		 3havA-1m2wA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 6 VAL A 481
LEU A 448
ILE A 390
ALA A 409
LEU A 476
 None
 1.40A 3kk6B-1m2wA:
undetectable		 3kk6B-1m2wA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 PRO A 225
SER A 188
GLY A 196
MET A 228
LYS A 295
 None
None
None
None
MTL  A5600 (-2.8A)
 1.44A 3lsfB-1m2wA:
0.0
3lsfE-1m2wA:
undetectable		 3lsfB-1m2wA:
18.79
3lsfE-1m2wA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 TYR A 354
MET A 294
ASN A 300
LEU A 299
 None
None
MTL  A5600 (-3.2A)
MTL  A5600 ( 4.7A)
 1.50A 3lslG-1m2wA:
undetectable		 3lslG-1m2wA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 0.93A 3pghC-1m2wA:
undetectable		 3pghC-1m2wA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 0.98A 3rr3A-1m2wA:
undetectable		 3rr3A-1m2wA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 0.99A 3rr3B-1m2wA:
undetectable		 3rr3B-1m2wA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		3 / 3 TRP A  58
TRP A 277
THR A  46
 None
 1.35A 4bboB-1m2wA:
undetectable		 4bboB-1m2wA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A 169
LEU A 119
MET A 105
GLY A  62
 None
 1.06A 4hbfA-1m2wA:
0.0		 4hbfA-1m2wA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 ARG A  39
GLY A  89
PRO A 234
THR A 233
 None
None
None
NAD  A5500 (-4.5A)
 1.09A 4l1aB-1m2wA:
0.0		 4l1aB-1m2wA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A 448
VAL A 438
ASP A 428
ILE A 426
 None
 0.86A 4l4cB-1m2wA:
0.0		 4l4cB-1m2wA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 4 ILE A 102
VAL A  63
VAL A  34
ARG A  39
 None
None
NAD  A5500 (-4.8A)
None
 1.08A 4m6tA-1m2wA:
0.0		 4m6tA-1m2wA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A 455
ILE A 454
ARG A 430
VAL A 438
 None
 1.40A 4mk4B-1m2wA:
1.6		 4mk4B-1m2wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 GLU A 267
THR A 285
HIS A  41
ASN A 195
 None
 1.34A 4pfjB-1m2wA:
4.7		 4pfjB-1m2wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 THR A 389
TYR A 334
GLY A 301
GLY A 297
 None
 0.87A 4rdxA-1m2wA:
undetectable		 4rdxA-1m2wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 412
GLY A 378
ASP A 377
LEU A 312
ALA A 409
 None
 1.13A 5h5fA-1m2wA:
undetectable		 5h5fA-1m2wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 1.07A 5iktA-1m2wA:
undetectable		 5iktA-1m2wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 THR A 389
ARG A 392
LEU A 393
ASP A 396
 None
 1.14A 5tdzA-1m2wA:
0.4		 5tdzA-1m2wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 10 ILE A 459
VAL A 406
LEU A 405
PHE A 465
GLU A 401
 None
 1.29A 5tixB-1m2wA:
undetectable		 5tixB-1m2wA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 ASP A  47
THR A  46
TYR A  45
LEU A  85
 None
 1.04A 5x19A-1m2wA:
0.0
5x19C-1m2wA:
0.0
5x19P-1m2wA:
0.0		 5x19A-1m2wA:
22.56
5x19C-1m2wA:
18.97
5x19P-1m2wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ASP A  47
THR A  46
TYR A  45
LEU A  85
 None
 1.08A 5x1bA-1m2wA:
0.0
5x1bC-1m2wA:
0.0
5x1bP-1m2wA:
undetectable		 5x1bA-1m2wA:
22.56
5x1bC-1m2wA:
18.97
5x1bP-1m2wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A 184
VAL A 165
LEU A 115
LEU A 119
 None
 0.88A 6e43A-1m2wA:
0.0		 6e43A-1m2wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A 184
VAL A 165
LEU A 115
LEU A 119
 None
 0.91A 6e43B-1m2wA:
0.0		 6e43B-1m2wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A 184
VAL A 165
LEU A 115
LEU A 119
 None
 0.87A 6e43C-1m2wA:
0.0		 6e43C-1m2wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A 184
VAL A 165
LEU A 115
LEU A 119
 None
 0.99A 6e43D-1m2wA:
0.0		 6e43D-1m2wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASP A 190
ASP A  69
LEU A  76
HIS A  31
ILE A  60
 NAD  A5500 (-3.6A)
NAD  A5500 (-3.0A)
None
None
None
 1.32A 6fzbB-1m2wA:
0.0		 6fzbB-1m2wA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 9 ILE A 459
ILE A 394
GLU A 453
VAL A 387
ILE A 390
 None
 1.46A 6hloA-1m2wA:
4.3		 6hloA-1m2wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A  65
ALA A  30
CYH A 137
LEU A 203
LEU A 119
 NAD  A5500 ( 4.6A)
None
None
None
None
 0.91A 6ie8A-1m2wA:
0.0		 6ie8A-1m2wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A  56
ILE A  99
GLY A 100
ASP A  80
PRO A  18
 None
 1.04A 6iftA-1m2wA:
undetectable		 6iftA-1m2wA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 8 LEU A  85
ASP A  47
THR A  46
TYR A  45
 None
 1.13A 6nknC-1m2wA:
undetectable
6nknN-1m2wA:
0.0
6nknP-1m2wA:
0.0		 6nknC-1m2wA:
18.97
6nknN-1m2wA:
22.56
6nknP-1m2wA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1m2w MANNITOL
DEHYDROGENASE
(Pseudomonas
fluorescens) 		4 / 7 ASP A  47
THR A  46
TYR A  45
LEU A  85
 None
 1.15A 6nmfA-1m2wA:
0.0
6nmfC-1m2wA:
0.0
6nmfP-1m2wA:
0.0		 6nmfA-1m2wA:
22.56
6nmfC-1m2wA:
18.97
6nmfP-1m2wA:
18.97