SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		3 / 3 PHE A 128
TYR A  55
TYR A  73
 None
 0.97A 1x70B-1m2xA:
0.5		 1x70B-1m2xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		3 / 3 LYS A 167
ASP A  84
CYH A 221
 MCO  A 811 ( 2.7A)
None
ZN  A 902 (-2.3A)
 1.11A 2br4F-1m2xA:
undetectable		 2br4F-1m2xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 12 ALA A  69
ASP A  90
LYS A  91
GLY A 124
LEU A 125
 None
 1.21A 2nv4B-1m2xA:
undetectable		 2nv4B-1m2xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		3 / 3 LYS A  43
GLU A  45
TRP A 277
 None
 0.74A 3v4tH-1m2xA:
0.0		 3v4tH-1m2xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		7 / 9 TYR A  67
TRP A  87
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
MCO  A 811 ( 4.8A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.60A 4c1dA-1m2xA:
32.2		 4c1dA-1m2xA:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		8 / 10 TYR A  67
TRP A  87
HIS A 116
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 None
MCO  A 811 ( 4.8A)
ZN  A 901 (-3.3A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.54A 4c1dB-1m2xA:
32.2		 4c1dB-1m2xA:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		6 / 11 HIS A 116
HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A 901 (-3.3A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.30A 4c1fA-1m2xA:
30.3
4c1fB-1m2xA:
30.0		 4c1fA-1m2xA:
34.32
4c1fB-1m2xA:
34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		7 / 9 HIS A 116
HIS A 118
ASP A 120
HIS A 196
CYH A 221
GLY A 232
HIS A 263
 ZN  A 901 (-3.3A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
None
ZN  A 902 (-3.2A)
 0.51A 4c1hA-1m2xA:
32.3		 4c1hA-1m2xA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 9 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.16A 4exsA-1m2xA:
29.2		 4exsA-1m2xA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 8 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.21A 4exsB-1m2xA:
29.1		 4exsB-1m2xA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		3 / 3 ASP A 265
LYS A 224
LEU A 289
 None
 0.90A 4ptjA-1m2xA:
undetectable		 4ptjA-1m2xA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		4 / 8 ILE A 113
LEU A  48
VAL A  75
LEU A  74
 None
 0.96A 4r38B-1m2xA:
undetectable		 4r38B-1m2xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 8 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.29A 5a5zA-1m2xA:
29.2		 5a5zA-1m2xA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 7 HIS A 196
CYH A 221
LYS A 224
GLY A 232
HIS A 263
 ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
None
None
ZN  A 902 (-3.2A)
 0.70A 5a5zC-1m2xA:
29.3		 5a5zC-1m2xA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 11 HIS A 116
HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A 901 (-3.3A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-3.2A)
 0.88A 5ayaA-1m2xA:
18.4		 5ayaA-1m2xA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		4 / 8 GLY A 262
ALA A  69
CYH A 221
GLY A 220
 None
None
ZN  A 902 (-2.3A)
None
 0.73A 5vw9A-1m2xA:
undetectable		 5vw9A-1m2xA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		5 / 8 HIS A 118
ASP A 120
HIS A 196
CYH A 221
HIS A 263
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.5A)
ZN  A 901 ( 3.2A)
ZN  A 902 (-2.3A)
ZN  A 902 (-3.2A)
 0.19A 5zj8A-1m2xA:
29.3		 5zj8A-1m2xA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1m2x CLASS B
CARBAPENEMASE BLAB-1
(Elizabethkingia
meningoseptica) 		4 / 7 THR A 136
ARG A 121
HIS A 196
ASP A  84
 None
ZN  A 902 ( 4.8A)
ZN  A 901 ( 3.2A)
None
 1.12A 6mn4E-1m2xA:
0.4		 6mn4E-1m2xA:
19.49