SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m3u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 8 LEU A 137
VAL A 199
LEU A 195
ALA A 175
 None
 0.87A 1fiqC-1m3uA:
undetectable		 1fiqC-1m3uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 8 LEU A  42
ILE A 212
GLU A 181
VAL A 179
ILE A 200
 KPL  A 265 (-4.9A)
KPL  A 265 ( 4.0A)
KPL  A 265 (-3.0A)
None
None
 1.38A 1linA-1m3uA:
undetectable		 1linA-1m3uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 11 THR A 140
PRO A 141
THR A  69
ALA A 108
VAL A 103
 None
KPL  A 265 (-4.5A)
None
None
None
 0.96A 1rv7A-1m3uA:
0.0
1rv7B-1m3uA:
0.0		 1rv7A-1m3uA:
17.80
1rv7B-1m3uA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 GLU A  36
ASP A  35
ARG A 245
ALA A  20
ILE A  22
 None
 1.46A 1s14B-1m3uA:
0.3		 1s14B-1m3uA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 THR A  21
THR A  23
VAL A 214
GLY A 203
LEU A 177
 None
KPL  A 265 (-4.1A)
KPL  A 265 (-4.7A)
None
None
 1.14A 2cbrA-1m3uA:
undetectable		 2cbrA-1m3uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 7 LEU A 139
THR A 140
PRO A 141
GLY A 135
 None
None
KPL  A 265 (-4.5A)
None
 0.90A 2ddwB-1m3uA:
undetectable		 2ddwB-1m3uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		6 / 12 LEU A 187
ALA A 167
ILE A 197
GLY A 135
ALA A 188
ILE A 191
 None
 1.20A 2nmzA-1m3uA:
undetectable		 2nmzA-1m3uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 MET A 215
HIS A 216
GLY A  44
LEU A  81
ASP A  26
 None
None
KPL  A 265 (-3.2A)
None
None
 1.19A 3i5uA-1m3uA:
undetectable		 3i5uA-1m3uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 MET A 215
HIS A 216
GLY A  44
LEU A  81
ASP A  26
 None
None
KPL  A 265 (-3.2A)
None
None
 1.18A 3i5uB-1m3uA:
undetectable		 3i5uB-1m3uA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 LEU A 195
GLY A 174
ILE A   6
VAL A 199
ILE A 197
 None
 1.01A 3nu3A-1m3uA:
undetectable		 3nu3A-1m3uA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 11 VAL A  43
LEU A  42
VAL A 103
GLY A 107
ALA A 108
 None
KPL  A 265 (-4.9A)
None
None
None
 1.06A 3pghB-1m3uA:
0.0		 3pghB-1m3uA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 5 LEU A 180
LEU A 163
GLY A 160
GLY A 154
 None
 0.68A 3si7C-1m3uA:
0.0
3si7D-1m3uA:
0.0		 3si7C-1m3uA:
20.21
3si7D-1m3uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 8 LEU A 137
VAL A 199
LEU A 195
ALA A 175
 None
 0.89A 3uniB-1m3uA:
undetectable		 3uniB-1m3uA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 6 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 0.96A 4f3tA-1m3uA:
0.0		 4f3tA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 6 ILE A 212
GLY A 203
VAL A 183
HIS A 136
 KPL  A 265 ( 4.0A)
None
None
KPL  A 265 (-4.5A)
 1.04A 4oltB-1m3uA:
undetectable		 4oltB-1m3uA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		3 / 3 PRO A  86
LEU A  85
GLN A  95
 None
 0.67A 4pevB-1m3uA:
undetectable		 4pevB-1m3uA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 5 LEU A 163
ASP A 166
LEU A 180
THR A 140
 None
 1.17A 4wozF-1m3uA:
13.5
4wozH-1m3uA:
13.4		 4wozF-1m3uA:
23.77
4wozH-1m3uA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 7 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 0.93A 4z4fA-1m3uA:
undetectable		 4z4fA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 6 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 1.03A 4z4gA-1m3uA:
undetectable		 4z4gA-1m3uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 8 LEU A 126
ASN A  99
ALA A 100
VAL A 103
 None
 0.48A 4zbqA-1m3uA:
undetectable		 4zbqA-1m3uA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 12 GLY A 160
GLY A 156
ALA A 188
ILE A 191
LEU A 163
 None
 1.24A 5bw4B-1m3uA:
undetectable		 5bw4B-1m3uA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		3 / 3 LEU A 213
PHE A 219
ILE A  22
 None
 0.66A 5dzk1-1m3uA:
undetectable
5dzkF-1m3uA:
0.9
5dzkM-1m3uA:
0.0		 5dzk1-1m3uA:
22.22
5dzkF-1m3uA:
21.71
5dzkM-1m3uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		5 / 10 ALA A  96
ALA A 100
VAL A 131
LEU A 119
VAL A 133
 None
 1.33A 5eb5B-1m3uA:
undetectable		 5eb5B-1m3uA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE
(Escherichia
coli) 		4 / 7 LEU A 213
LYS A 231
GLU A 250
TYR A 256
 None
 0.88A 5t7bA-1m3uA:
undetectable		 5t7bA-1m3uA:
14.88