SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		9 / 10 PHE A  32
ASP A  35
ASP A  40
GLU A  82
SER A 117
ALA A 120
ASP A 152
THR A 155
ASP A 179
 COA  A 600 ( 3.7A)
KAN  A 500 (-3.4A)
KAN  A 500 (-3.4A)
KAN  A 500 (-3.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
KAN  A 500 ( 4.3A)
 0.50A 1m4dA-1m4iA:
35.1		 1m4dA-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 117
SER A 119
ALA A 120
ASP A 152
THR A 155
 KAN  A 500 (-3.4A)
COA  A 600 ( 4.0A)
KAN  A 500 ( 4.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
 0.56A 1m4dA-1m4iA:
35.1		 1m4dA-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		8 / 9 ASP A  35
ASP A  40
GLU A  82
SER A 117
ALA A 120
ASP A 152
THR A 155
ASP A 179
 KAN  A 500 (-3.4A)
KAN  A 500 (-3.4A)
KAN  A 500 (-3.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
KAN  A 500 ( 4.3A)
 0.56A 1m4dB-1m4iA:
33.0		 1m4dB-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		6 / 9 GLU A  82
SER A 117
SER A 119
ALA A 120
ASP A 152
THR A 155
 KAN  A 500 (-3.8A)
KAN  A 500 (-3.4A)
COA  A 600 ( 4.0A)
KAN  A 500 ( 4.8A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
 0.60A 1m4dB-1m4iA:
33.0		 1m4dB-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		8 / 9 ASP A  35
ASP A  40
GLU A  82
GLY A  83
SER A 117
SER A 119
ASP A 152
ASP A 179
 KAN  A 500 (-3.4A)
KAN  A 500 (-3.4A)
KAN  A 500 (-3.8A)
KAN  A 500 (-3.7A)
KAN  A 500 (-3.4A)
COA  A 600 ( 4.0A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.3A)
 0.69A 1m4gA-1m4iA:
34.5		 1m4gA-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		9 / 9 ASP A  35
ASP A  40
GLU A  82
GLY A  83
SER A 117
SER A 119
ASP A 152
THR A 155
ASP A 179
 KAN  A 500 (-3.4A)
KAN  A 500 (-3.4A)
KAN  A 500 (-3.8A)
KAN  A 500 (-3.7A)
KAN  A 500 (-3.4A)
COA  A 600 ( 4.0A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
KAN  A 500 ( 4.3A)
 0.70A 1m4gB-1m4iA:
32.7		 1m4gB-1m4iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		5 / 9 ASP A  35
SER A 117
SER A 119
ASP A 152
THR A 155
 KAN  A 500 (-3.4A)
KAN  A 500 (-3.4A)
COA  A 600 ( 4.0A)
KAN  A 500 (-3.4A)
KAN  A 500 ( 4.7A)
 1.01A 1m4gB-1m4iA:
32.7		 1m4gB-1m4iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  10
MET A  48
MET A  27
 None
 1.00A 2vavF-1m4iA:
undetectable		 2vavF-1m4iA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 165
ASN A  74
CYH A  78
TYR A  80
LEU A 171
 None
 1.07A 3bgrA-1m4iA:
0.1
3bgrB-1m4iA:
0.0		 3bgrA-1m4iA:
13.82
3bgrB-1m4iA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  96
LEU A  99
LEU A 125
VAL A  81
GLY A  83
 COA  A 600 (-3.8A)
None
None
None
KAN  A 500 (-3.7A)
 1.25A 3pghB-1m4iA:
0.0		 3pghB-1m4iA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 176
VAL A 147
THR A 149
 None
 0.84A 3pwrA-1m4iA:
undetectable		 3pwrA-1m4iA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 176
VAL A 147
THR A 149
 None
 0.88A 3tl9A-1m4iA:
undetectable		 3tl9A-1m4iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  62
LEU A  99
LEU A 100
TYR A 126
VAL A  96
 None
None
None
None
COA  A 600 (-3.8A)
 1.49A 6g2pB-1m4iA:
undetectable		 6g2pB-1m4iA:
17.03