SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 VAL A  96
ASP A  95
PHE A  74
THR A 133
ARG A 121
 None
 1.30A 1ia0B-1m4xA:
undetectable		 1ia0B-1m4xA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 TRP A 264
TYR A 417
LEU A 119
 None
 0.90A 1kxhA-1m4xA:
undetectable		 1kxhA-1m4xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ILE A 152
LEU A 151
VAL A  72
 None
 0.45A 1mz9B-1m4xA:
undetectable		 1mz9B-1m4xA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 ARG A 363
GLU A 229
HIS A 108
TYR A 116
 None
 0.94A 1nx9A-1m4xA:
undetectable		 1nx9A-1m4xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 ARG A 363
GLU A 229
HIS A 108
TYR A 116
 None
 0.95A 1nx9B-1m4xA:
undetectable		 1nx9B-1m4xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 ARG A 363
GLU A 229
HIS A 108
TYR A 116
 None
 0.94A 1nx9D-1m4xA:
3.5		 1nx9D-1m4xA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 VAL A  96
ASP A  95
PHE A  74
THR A 133
ARG A 121
 None
 1.30A 1tubB-1m4xA:
undetectable		 1tubB-1m4xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 LEU A 320
PHE A 371
LEU A 231
SER A 355
 None
 0.97A 1wrlC-1m4xA:
undetectable
1wrlD-1m4xA:
undetectable		 1wrlC-1m4xA:
11.33
1wrlD-1m4xA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 PHE A 334
ASN A 335
GLY A 350
THR A 115
 None
 1.07A 1ykiA-1m4xA:
0.0
1ykiB-1m4xA:
0.0		 1ykiA-1m4xA:
18.64
1ykiB-1m4xA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 PHE A 334
ASN A 335
GLY A 350
THR A 115
 None
 1.08A 1ykiC-1m4xA:
0.0
1ykiD-1m4xA:
0.0		 1ykiC-1m4xA:
18.64
1ykiD-1m4xA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ASP A 125
ARG A 126
ARG A 121
 None
 0.56A 2j9dA-1m4xA:
0.0
2j9dC-1m4xA:
0.1		 2j9dA-1m4xA:
13.70
2j9dC-1m4xA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 GLY A  82
GLY A  80
GLY A 142
THR A  84
ASP A 299
 None
 0.87A 2pxcA-1m4xA:
undetectable		 2pxcA-1m4xA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 ASN A 280
GLY A 289
ALA A 288
ASP A 299
 None
 0.88A 4eyrB-1m4xA:
undetectable		 4eyrB-1m4xA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 5 LEU A 414
TRP A 264
ILE A 318
ASN A 376
 None
 1.49A 4i00A-1m4xA:
undetectable		 4i00A-1m4xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 THR A 238
THR A 412
ALA A 413
ASN A 415
TYR A 352
 None
 1.28A 4u15B-1m4xA:
undetectable		 4u15B-1m4xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 LEU A  98
ILE A 228
GLY A 432
LEU A 168
 None
 0.90A 5eseA-1m4xA:
undetectable		 5eseA-1m4xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 PHE A  74
ILE A  70
THR A  58
VAL A  56
VAL A  50
 None
 1.40A 5jkwA-1m4xA:
0.0		 5jkwA-1m4xA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 6 HIS A 108
TYR A 129
ARG A 121
GLN A 157
 None
 1.47A 5kkzA-1m4xA:
0.0
5kkzG-1m4xA:
0.0		 5kkzA-1m4xA:
21.08
5kkzG-1m4xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 7 VAL A 206
PHE A 155
LEU A 175
THR A  58
 None
 0.85A 5m78A-1m4xA:
undetectable		 5m78A-1m4xA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 6 TYR A 300
THR A 297
ASP A 299
GLY A 301
 None
 1.03A 5mraA-1m4xA:
undetectable
5mraB-1m4xA:
undetectable		 5mraA-1m4xA:
16.79
5mraB-1m4xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1m4x PBCV-1 VIRUS CAPSID
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 GLY A 185
GLN A 184
THR A  85
PHE A  52
 None
 1.03A 6eqpA-1m4xA:
undetectable		 6eqpA-1m4xA:
9.69