SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 12 GLY A  38
VAL A  97
LEU A  71
ALA A  74
PHE A  60
 None
 0.92A 1gseB-1m4yA:
undetectable		 1gseB-1m4yA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 GLY A  16
THR A 162
ILE A 166
GLY A 123
ALA A 129
 None
 0.89A 1utdP-1m4yA:
0.0
1utdQ-1m4yA:
0.1		 1utdP-1m4yA:
20.13
1utdQ-1m4yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 10 ILE A 122
ALA A  47
LEU A  94
ALA A  93
ILE A 103
 None
 1.03A 3falC-1m4yA:
undetectable		 3falC-1m4yA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 10 VAL A  34
GLY A  45
GLN A  11
ILE A 122
GLY A  15
 None
 1.17A 3km6A-1m4yA:
undetectable		 3km6A-1m4yA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.86A 3mg0H-1m4yA:
21.0
3mg0I-1m4yA:
18.9		 3mg0H-1m4yA:
21.79
3mg0I-1m4yA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.88A 3mg0K-1m4yA:
20.6
3mg0L-1m4yA:
17.0		 3mg0K-1m4yA:
25.00
3mg0L-1m4yA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
SER A 124
 None
 0.41A 3mg0K-1m4yA:
20.6
3mg0L-1m4yA:
17.0		 3mg0K-1m4yA:
25.00
3mg0L-1m4yA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 12 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.88A 3mg0Y-1m4yA:
10.2
3mg0Z-1m4yA:
6.1		 3mg0Y-1m4yA:
25.00
3mg0Z-1m4yA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 12 THR A   1
THR A  21
LYS A  33
ALA A  47
SER A 124
 None
 0.43A 3mg0Y-1m4yA:
10.2
3mg0Z-1m4yA:
6.1		 3mg0Y-1m4yA:
25.00
3mg0Z-1m4yA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		4 / 8 VAL A  34
GLY A  45
ILE A 122
GLY A  16
 None
 0.80A 3n9jB-1m4yA:
undetectable		 3n9jB-1m4yA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		6 / 10 LEU A 130
ASP A  17
ILE A 166
VAL A 148
GLY A  45
LEU A   4
 None
 1.40A 3ogqA-1m4yA:
undetectable		 3ogqA-1m4yA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.96A 4qvvH-1m4yA:
20.0		 4qvvH-1m4yA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.96A 4qvvV-1m4yA:
21.2		 4qvvV-1m4yA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.92A 5bxnV-1m4yA:
21.1
5bxnW-1m4yA:
19.4		 5bxnV-1m4yA:
22.92
5bxnW-1m4yA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.95A 5d0xV-1m4yA:
21.2		 5d0xV-1m4yA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		3 / 3 LYS A  33
LEU A  43
ILE A 168
 None
 0.68A 5kc0A-1m4yA:
undetectable		 5kc0A-1m4yA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 12 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.89A 5l5zH-1m4yA:
20.0
5l5zI-1m4yA:
18.9		 5l5zH-1m4yA:
22.92
5l5zI-1m4yA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 12 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.89A 5l5zV-1m4yA:
21.1
5l5zW-1m4yA:
19.4		 5l5zV-1m4yA:
22.92
5l5zW-1m4yA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
GLY A  48
TYR A 161
 None
 0.91A 5lf3K-1m4yA:
21.3
5lf3L-1m4yA:
18.3		 5lf3K-1m4yA:
23.56
5lf3L-1m4yA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 10 THR A   1
THR A  21
LYS A  33
ALA A  47
GLY A  48
 None
 0.88A 5lf3V-1m4yA:
21.3
5lf3W-1m4yA:
19.1		 5lf3V-1m4yA:
23.65
5lf3W-1m4yA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1m4y ATP-DEPENDENT
PROTEASE HSLV
(Thermotoga
maritima) 		5 / 11 THR A   1
THR A  21
LYS A  33
GLY A  48
TYR A 161
 None
 0.93A 5lf3Y-1m4yA:
9.4
5lf3Z-1m4yA:
18.3		 5lf3Y-1m4yA:
23.56
5lf3Z-1m4yA:
25.23