SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.75A 1d0vA-1m54A:
undetectable		 1d0vA-1m54A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 TRP A 390
ARG A 182
THR A 383
 None
 0.85A 1df7A-1m54A:
0.0		 1df7A-1m54A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.75A 1jhaA-1m54A:
undetectable		 1jhaA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.74A 1jhqA-1m54A:
undetectable		 1jhqA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 279
GLY A 259
LEU A 315
GLY A 256
 None
PLP  A1110 (-3.6A)
None
PLP  A1110 (-3.2A)
 0.74A 1jhvA-1m54A:
undetectable		 1jhvA-1m54A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 374
VAL A 372
CYH A 370
ALA A 361
 None
 1.28A 1mz9E-1m54A:
0.0		 1mz9E-1m54A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 120
GLY A 153
ALA A 186
LEU A 220
ASN A 149
 None
None
None
None
PLP  A1110 (-3.6A)
 1.35A 1nw3A-1m54A:
2.4		 1nw3A-1m54A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.02A 1rs7A-1m54A:
0.0		 1rs7A-1m54A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.08A 1rs7B-1m54A:
0.0		 1rs7B-1m54A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 338
ILE A 373
GLY A 348
ALA A 357
LEU A 251
 None
 1.02A 1vptA-1m54A:
1.9		 1vptA-1m54A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 HIS A 203
ASP A 221
ASN A 228
 None
None
PLP  A1110 ( 4.5A)
 0.69A 1wg8B-1m54A:
3.5		 1wg8B-1m54A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A  81
ILE A 122
THR A 150
ASN A 149
LEU A 136
 None
None
None
PLP  A1110 (-3.6A)
None
 1.32A 2ft9A-1m54A:
0.0		 2ft9A-1m54A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR A 262
ASP A 281
SER A 326
 None
 0.86A 2nxeA-1m54A:
3.2		 2nxeA-1m54A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ASN A 380
GLY A 153
THR A 146
ILE A 167
LEU A 181
 None
 1.19A 3bf1A-1m54A:
undetectable
3bf1B-1m54A:
0.9		 3bf1A-1m54A:
22.31
3bf1B-1m54A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ASN A 380
GLY A 153
THR A 146
ILE A 167
LEU A 181
 None
 1.13A 3bf1C-1m54A:
undetectable
3bf1D-1m54A:
1.3		 3bf1C-1m54A:
22.31
3bf1D-1m54A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 307
THR A 296
LEU A 287
ASP A 281
ALA A 288
 None
 1.24A 3d91A-1m54A:
undetectable		 3d91A-1m54A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 158
GLY A 115
ILE A 127
LEU A 154
SER A 123
 None
 1.18A 3gyqA-1m54A:
undetectable
3gyqB-1m54A:
undetectable		 3gyqA-1m54A:
23.31
3gyqB-1m54A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A 158
GLY A 115
ILE A 127
LEU A 154
SER A 123
 None
 1.13A 3gyqB-1m54A:
undetectable		 3gyqB-1m54A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 8 LEU A 315
THR A 257
GLY A 305
THR A 353
ILE A 373
 None
PLP  A1110 (-3.3A)
PLP  A1110 (-3.9A)
None
None
 1.24A 3jusB-1m54A:
undetectable		 3jusB-1m54A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A 315
THR A 257
GLY A 305
THR A 353
ILE A 373
 None
PLP  A1110 (-3.3A)
PLP  A1110 (-3.9A)
None
None
 1.24A 3jusB-1m54A:
0.0		 3jusB-1m54A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 SER A 117
GLY A 115
SER A 123
 None
 0.66A 3loqA-1m54A:
2.9		 3loqA-1m54A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
VAL A 372
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.15A 3u9fB-1m54A:
0.1
3u9fC-1m54A:
0.1		 3u9fB-1m54A:
19.73
3u9fC-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
ALA A 335
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.12A 3u9fD-1m54A:
0.2
3u9fE-1m54A:
0.0		 3u9fD-1m54A:
19.73
3u9fE-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
VAL A 372
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.11A 3u9fD-1m54A:
0.2
3u9fE-1m54A:
0.0		 3u9fD-1m54A:
19.73
3u9fE-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
ALA A 335
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.29A 3u9fG-1m54A:
0.0
3u9fH-1m54A:
0.0		 3u9fG-1m54A:
19.73
3u9fH-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
VAL A 372
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.00A 3u9fH-1m54A:
0.0
3u9fI-1m54A:
0.0		 3u9fH-1m54A:
19.73
3u9fI-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 SER A 326
SER A 254
LEU A 374
VAL A 372
CYH A 346
 None
PLP  A1110 ( 4.3A)
None
None
None
 1.09A 3u9fJ-1m54A:
undetectable
3u9fK-1m54A:
undetectable		 3u9fJ-1m54A:
19.73
3u9fK-1m54A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 149
ASP A 376
ASN A 380
 PLP  A1110 (-3.6A)
PLP  A1110 (-3.2A)
None
 0.76A 4agaA-1m54A:
undetectable		 4agaA-1m54A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1110 (-3.2A)
PLP  A1110 (-4.5A)
None
PLP  A1110 ( 4.3A)
 1.04A 4kcnA-1m54A:
0.0		 4kcnA-1m54A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A 154
GLY A 153
ILE A 122
GLN A 222
 None
 1.20A 4ma8C-1m54A:
0.0		 4ma8C-1m54A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 306
VAL A 358
SER A 326
LEU A 338
LEU A 374
 PLP  A1110 (-4.5A)
None
None
None
None
 1.45A 4qztA-1m54A:
0.0		 4qztA-1m54A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 MET A 391
GLU A 329
GLY A 348
GLY A 347
 None
 0.96A 5x7pB-1m54A:
1.8		 5x7pB-1m54A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR A  87
GLU A 239
HIS A 232
 None
 0.89A 5xioA-1m54A:
undetectable		 5xioA-1m54A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR A  87
GLU A 239
HIS A 232
 None
 0.89A 5xiqB-1m54A:
undetectable		 5xiqB-1m54A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 THR A  87
GLU A 239
HIS A 232
 None
 0.91A 5xiqD-1m54A:
undetectable		 5xiqD-1m54A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 120
LEU A 251
HIS A 232
ALA A 231
GLN A 243
 None
 1.13A 6ew0D-1m54A:
undetectable		 6ew0D-1m54A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1m54 CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 120
LEU A 251
HIS A 232
ALA A 231
GLN A 243
 None
 1.14A 6ew0I-1m54A:
undetectable		 6ew0I-1m54A:
13.88