SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
None
HEM  A 201 (-4.7A)
None
 1.47A 1k2tA-1m59A:
undetectable
1k2tB-1m59A:
undetectable		 1k2tA-1m59A:
10.65
1k2tB-1m59A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.50A 1mmvA-1m59A:
undetectable
1mmvB-1m59A:
undetectable		 1mmvA-1m59A:
10.65
1mmvB-1m59A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 6 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.39A 1om5A-1m59A:
undetectable
1om5B-1m59A:
0.0		 1om5A-1m59A:
10.60
1om5B-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 8 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.43A 3b3pA-1m59A:
undetectable
3b3pB-1m59A:
undetectable		 3b3pA-1m59A:
10.60
3b3pB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.50A 3hsnA-1m59A:
undetectable
3hsnB-1m59A:
undetectable		 3hsnA-1m59A:
10.60
3hsnB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
None
HEM  A 201 (-4.7A)
None
 1.44A 3ufpA-1m59A:
undetectable
3ufpB-1m59A:
undetectable		 3ufpA-1m59A:
10.60
3ufpB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.44A 3ufpA-1m59A:
undetectable
3ufpB-1m59A:
undetectable		 3ufpA-1m59A:
10.60
3ufpB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 6 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
None
HEM  A 201 (-4.7A)
None
 1.42A 3ufrA-1m59A:
0.0
3ufrB-1m59A:
undetectable		 3ufrA-1m59A:
10.60
3ufrB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 3ufsA-1m59A:
0.0
3ufsB-1m59A:
0.0		 3ufsA-1m59A:
10.60
3ufsB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 4fvxA-1m59A:
undetectable
4fvxB-1m59A:
undetectable		 4fvxA-1m59A:
10.60
4fvxB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 4uh2A-1m59A:
undetectable
4uh2B-1m59A:
undetectable		 4uh2A-1m59A:
10.60
4uh2B-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 4v3vA-1m59A:
0.0
4v3vB-1m59A:
0.0		 4v3vA-1m59A:
10.60
4v3vB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		5 / 9 ALA A  54
LEU A  36
LEU A  23
LEU A  46
ARG A  47
 HEM  A 201 ( 4.1A)
None
None
None
None
 1.25A 4x30A-1m59A:
undetectable		 4x30A-1m59A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 6 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.40A 5ad9A-1m59A:
undetectable
5ad9B-1m59A:
0.0		 5ad9A-1m59A:
10.60
5ad9B-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 5agkA-1m59A:
undetectable
5agkB-1m59A:
undetectable		 5agkA-1m59A:
10.60
5agkB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.50A 5agoA-1m59A:
0.0
5agoB-1m59A:
0.0		 5agoA-1m59A:
10.60
5agoB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.46A 5unwA-1m59A:
0.0
5unwB-1m59A:
undetectable		 5unwA-1m59A:
10.60
5unwB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.49A 5vuvA-1m59A:
undetectable
5vuvB-1m59A:
undetectable		 5vuvA-1m59A:
10.60
5vuvB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.44A 5vuyA-1m59A:
undetectable
5vuyB-1m59A:
undetectable		 5vuyA-1m59A:
10.60
5vuyB-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.50A 5vv3A-1m59A:
0.0
5vv3B-1m59A:
0.0		 5vv3A-1m59A:
10.60
5vv3B-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.47A 5vv5A-1m59A:
0.0
5vv5B-1m59A:
0.0		 5vv5A-1m59A:
10.60
5vv5B-1m59A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.48A 6auuA-1m59A:
0.0
6auuB-1m59A:
0.0		 6auuA-1m59A:
21.95
6auuB-1m59A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m59 CYTOCHROME B5
(Bos
taurus) 		4 / 7 PHE A  58
GLU A  56
ARG A  68
VAL A  61
 HEM  A 201 (-4.7A)
None
None
None
 1.46A 6av1A-1m59A:
0.0
6av1B-1m59A:
0.0		 6av1A-1m59A:
22.99
6av1B-1m59A:
22.99