SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
4 / 5 ALA A 279
ILE A 291
ASN A 165
ILE A 249
None
1.00A 2h4jA-1m5hA:
undetectable
2h4jA-1m5hA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
3 / 3 ILE A 168
ILE A 201
LEU A 296
None
0.56A 2prgA-1m5hA:
undetectable
2prgA-1m5hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
5 / 8 GLU A 113
LEU A  84
LEU A  88
VAL A  23
ILE A  74
None
1.32A 2uxpA-1m5hA:
undetectable
2uxpA-1m5hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
5 / 10 ILE A  56
ILE A  74
VAL A  23
GLY A 107
PRO A  66
None
1.17A 3elzC-1m5hA:
0.0
3elzC-1m5hA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
4 / 4 ALA A 179
ALA A 182
ALA A 183
ALA A 186
None
0.14A 4oadA-1m5hA:
0.5
4oadA-1m5hA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
4 / 6 LEU A 296
ILE A 291
ALA A  13
THR A  11
None
0.70A 4zf8A-1m5hA:
undetectable
4zf8A-1m5hA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
4 / 8 ARG A 262
GLU A 259
GLY A 264
LEU A 266
None
1.01A 5sxtB-1m5hA:
undetectable
5sxtB-1m5hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus)
5 / 12 LEU A 286
GLY A 287
SER A  46
ILE A  18
ASP A  17
None
1.10A 6bxmA-1m5hA:
undetectable
6bxmA-1m5hA:
23.77