SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 4 GLY A 264
LEU A 183
GLY A 262
ARG A 260
 None
 1.46A 1j7kA-1m5yA:
0.0		 1j7kA-1m5yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 7 SER A 261
GLU A 408
GLU A 409
GLU A 416
 None
 1.03A 1knyA-1m5yA:
0.0
1knyB-1m5yA:
undetectable		 1knyA-1m5yA:
20.19
1knyB-1m5yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 8 GLU A 416
SER A 261
GLU A 408
GLU A 409
 None
 1.13A 1knyA-1m5yA:
0.0
1knyB-1m5yA:
undetectable		 1knyA-1m5yA:
20.19
1knyB-1m5yA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 11 LEU A  45
ALA A  29
VAL A  49
LEU A  66
GLN A  69
 None
 1.40A 1kt6A-1m5yA:
0.0		 1kt6A-1m5yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 11 LEU A  45
ALA A  29
VAL A  49
LEU A  66
GLN A  69
 None
 1.40A 1kt7A-1m5yA:
undetectable		 1kt7A-1m5yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 5 PRO A 184
PRO A 182
ILE A 181
GLY A 264
 None
 0.93A 2jkjD-1m5yA:
0.2		 2jkjD-1m5yA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 5 PRO A 184
PRO A 182
ILE A 181
GLY A 264
 None
 0.92A 2jkjF-1m5yA:
0.0		 2jkjF-1m5yA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 5 ILE A 290
LEU A 377
ASP A 313
ALA A 324
 None
 0.96A 2opxA-1m5yA:
undetectable		 2opxA-1m5yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 8 PHE A 406
SER A 412
MET A 414
TRP A 413
 None
 1.32A 3nlyA-1m5yA:
0.0
3nlyB-1m5yA:
undetectable		 3nlyA-1m5yA:
24.48
3nlyB-1m5yA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		3 / 3 GLN A  69
ASP A 222
GLN A 224
 None
 0.80A 4aztA-1m5yA:
3.1		 4aztA-1m5yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 8 SER A 412
MET A 414
TRP A 413
PHE A 406
 None
 1.26A 4cx7A-1m5yA:
undetectable
4cx7B-1m5yA:
undetectable		 4cx7A-1m5yA:
21.70
4cx7B-1m5yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 11 ILE A 179
ALA A 216
GLY A 213
GLY A 232
ASN A 175
 None
 1.15A 4jdsA-1m5yA:
undetectable		 4jdsA-1m5yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 12 SER A 366
GLU A 379
ARG A 288
ILE A 290
ILE A 310
 None
 1.30A 4uroA-1m5yA:
undetectable		 4uroA-1m5yA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		3 / 3 ASP A 121
ARG A 117
TYR A 120
 None
 1.03A 5a7mA-1m5yA:
undetectable		 5a7mA-1m5yA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		3 / 3 ASP A 121
ARG A 117
TYR A 120
 None
 1.04A 5a7mB-1m5yA:
undetectable		 5a7mB-1m5yA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		3 / 3 LEU A 226
LEU A  66
ARG A  57
 None
 0.47A 5hnzB-1m5yA:
undetectable		 5hnzB-1m5yA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 12 GLY A 317
ARG A 288
SER A 329
ILE A 290
PHE A 328
 None
 1.41A 5igwA-1m5yA:
undetectable		 5igwA-1m5yA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		5 / 12 ASP A  26
GLU A  39
ARG A  67
GLY A  44
LEU A  45
 None
 1.05A 5m50B-1m5yA:
2.4		 5m50B-1m5yA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1m5y SURVIVAL PROTEIN
SURA
(Escherichia
coli) 		4 / 8 SER A 412
MET A 414
TRP A 413
PHE A 406
 None
 1.27A 5uo7A-1m5yA:
undetectable
5uo7B-1m5yA:
0.0		 5uo7A-1m5yA:
25.00
5uo7B-1m5yA:
25.00