SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		4 / 7 SER A 172
ASP A 174
SER A 149
LEU A  13
 None
 0.99A 2hdnE-1m66A:
0.0
2hdnF-1m66A:
undetectable
2hdnH-1m66A:
2.4		 2hdnE-1m66A:
10.09
2hdnF-1m66A:
20.57
2hdnH-1m66A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		4 / 7 SER A 149
LEU A  13
SER A 172
ASP A 174
 None
 0.98A 2hdnF-1m66A:
undetectable
2hdnG-1m66A:
0.0
2hdnH-1m66A:
2.4		 2hdnF-1m66A:
20.57
2hdnG-1m66A:
10.09
2hdnH-1m66A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.21A 2vcvD-1m66A:
undetectable		 2vcvD-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.19A 2vcvE-1m66A:
undetectable		 2vcvE-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.19A 2vcvH-1m66A:
undetectable		 2vcvH-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 339
LEU A 321
ALA A 220
LEU A 233
ALA A 232
 PLM  A 402 ( 4.9A)
None
PLM  A 402 ( 4.0A)
PLM  A 402 ( 4.3A)
PLM  A 402 ( 4.0A)
 1.20A 2vcvI-1m66A:
undetectable		 2vcvI-1m66A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 10 LEU A 151
LEU A  30
VAL A  33
ILE A  88
THR A 166
 None
 1.00A 2w9gA-1m66A:
undetectable		 2w9gA-1m66A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 10 LEU A 151
LEU A  30
VAL A  33
ILE A  88
THR A 166
 None
 1.11A 2w9hA-1m66A:
undetectable		 2w9hA-1m66A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		4 / 7 VAL A  33
TYR A  14
CYH A  38
ILE A 184
 None
 1.28A 2xz5B-1m66A:
undetectable
2xz5E-1m66A:
undetectable		 2xz5B-1m66A:
20.00
2xz5E-1m66A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 11 LEU A 151
LEU A  30
VAL A  33
ILE A  88
THR A 166
 None
 1.00A 3frbX-1m66A:
undetectable		 3frbX-1m66A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 LEU A 151
LEU A  30
VAL A  33
ILE A  88
THR A 166
 None
 0.99A 3freX-1m66A:
undetectable		 3freX-1m66A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 11 LEU A 151
LEU A  30
VAL A  33
ILE A  88
THR A 166
 None
 1.17A 3jw5A-1m66A:
undetectable		 3jw5A-1m66A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		4 / 5 VAL A  43
PHE A 101
ILE A  93
PHE A 102
 None
BCP  A 401 ( 4.9A)
BCP  A 401 (-4.0A)
None
 1.13A 3owxB-1m66A:
5.3		 3owxB-1m66A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ALA A 152
GLY A 202
THR A 245
LEU A 248
LEU A 308
 None
 0.98A 4n49A-1m66A:
undetectable		 4n49A-1m66A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		4 / 8 LYS A 313
ALA A 312
LEU A 308
LEU A 244
 None
 0.81A 4po0A-1m66A:
2.6		 4po0A-1m66A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 THR A 245
VAL A 255
GLY A 260
VAL A 209
VAL A 205
 None
 1.34A 5cp4A-1m66A:
0.0		 5cp4A-1m66A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ILE A 241
MET A 319
LEU A 238
THR A 245
GLY A 202
 None
 1.13A 5d4uA-1m66A:
6.5		 5d4uA-1m66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ILE A 241
MET A 319
LEU A 238
THR A 245
GLY A 202
 None
 1.11A 5d4uB-1m66A:
6.4		 5d4uB-1m66A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 GLU A  50
PHE A  91
ILE A  89
PHE A 101
GLY A 106
 None
None
None
BCP  A 401 ( 4.9A)
None
 1.31A 5esgA-1m66A:
undetectable		 5esgA-1m66A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 VAL A 168
LEU A 151
GLY A 153
PRO A 154
LEU A  15
 None
 0.96A 5ienA-1m66A:
0.0		 5ienA-1m66A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ILE A 241
LEU A 238
VAL A 205
GLY A 202
GLY A 252
 None
 1.17A 5nnaA-1m66A:
undetectable		 5nnaA-1m66A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ILE A 241
LEU A 238
VAL A 205
GLY A 202
GLY A 252
 None
 1.12A 5nnaB-1m66A:
undetectable		 5nnaB-1m66A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 12 ILE A 241
LEU A 238
VAL A 205
GLY A 202
GLY A 252
 None
 1.11A 5nnaC-1m66A:
undetectable		 5nnaC-1m66A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 9 VAL A 255
LEU A 248
ARG A 242
ALA A 247
ASP A 243
 None
 1.37A 6c2mB-1m66A:
0.0		 6c2mB-1m66A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 10 MET A 185
SER A 186
LEU A 258
SER A 169
LEU A 151
 None
 1.48A 6dlzB-1m66A:
2.6
6dlzC-1m66A:
3.5		 6dlzB-1m66A:
12.53
6dlzC-1m66A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
(Leishmania
mexicana) 		5 / 10 MET A 185
SER A 186
LEU A 258
SER A 169
LEU A 151
 None
 1.48A 6dm1B-1m66A:
2.5
6dm1C-1m66A:
3.2		 6dm1B-1m66A:
12.53
6dm1C-1m66A:
12.53