SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 11 ILE X  55
LEU X  43
GLY X 203
PHE X 142
VAL X  49
 None
 1.47A 1axwB-1m6eX:
undetectable		 1axwB-1m6eX:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 8 LEU X 134
ALA X  56
ILE X 143
CYH X  60
GLY X  59
 None
None
None
None
SAH  X2814 (-3.7A)
 1.07A 1sv9A-1m6eX:
undetectable		 1sv9A-1m6eX:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 PRO X 257
MET X 150
HIS X 188
ASP X 187
 None
SAL  X2000 ( 4.8A)
None
None
 1.43A 2lh8A-1m6eX:
0.0		 2lh8A-1m6eX:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		6 / 12 GLY X 203
LEU X 140
ALA X  54
ALA X  56
LEU X  73
VAL X  70
 None
 1.41A 2yqzB-1m6eX:
10.6		 2yqzB-1m6eX:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 LEU X 134
GLU X 198
PRO X 136
ARG X 195
 None
 1.30A 3ltwA-1m6eX:
0.0		 3ltwA-1m6eX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		5 / 9 ILE X 143
ALA X  56
VAL X 126
PHE X  95
LEU X 134
 None
 1.27A 3ti1A-1m6eX:
undetectable		 3ti1A-1m6eX:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 5 THR X  71
ILE X  74
LYS X  75
GLU X  78
 None
 1.04A 4ac9C-1m6eX:
undetectable		 4ac9C-1m6eX:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 5 THR X  71
ILE X  74
LYS X  75
GLU X  78
 None
 1.02A 4acaC-1m6eX:
undetectable		 4acaC-1m6eX:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 5 THR X  71
ILE X  74
LYS X  75
GLU X  78
 None
 0.95A 4acbC-1m6eX:
undetectable		 4acbC-1m6eX:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 PHE X 135
ARG X 137
ALA X  56
GLN X 197
 None
 1.09A 6b89B-1m6eX:
undetectable		 6b89B-1m6eX:
13.98