SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		4 / 8 VAL A  42
VAL A  44
ILE A  21
LEU A  58
 None
 0.82A 1igxA-1m6jA:
undetectable		 1igxA-1m6jA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		3 / 3 ALA A  71
VAL A  44
TRP A  12
 None
 0.89A 1kqeB-1m6jA:
undetectable
1kqeD-1m6jA:
undetectable		 1kqeB-1m6jA:
5.11
1kqeD-1m6jA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		3 / 3 TRP A  12
ALA A  71
VAL A  44
 None
 0.88A 1kqeB-1m6jA:
undetectable
1kqeD-1m6jA:
undetectable		 1kqeB-1m6jA:
5.11
1kqeD-1m6jA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		3 / 3 TRP A  12
ALA A  71
VAL A  44
 None
 0.87A 1kqeA-1m6jA:
undetectable
1kqeE-1m6jA:
undetectable		 1kqeA-1m6jA:
5.11
1kqeE-1m6jA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		5 / 10 GLY A 218
VAL A 221
ALA A 190
ASN A 225
ILE A 235
 None
 1.03A 1likA-1m6jA:
undetectable		 1likA-1m6jA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		3 / 3 ILE A  21
LEU A  24
VAL A  28
 None
 0.29A 1mz9B-1m6jA:
undetectable		 1mz9B-1m6jA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		4 / 7 GLU A  72
SER A  70
VAL A  46
VAL A  95
 None
 1.30A 3n61A-1m6jA:
0.3
3n61B-1m6jA:
0.0		 3n61A-1m6jA:
19.17
3n61B-1m6jA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		4 / 7 ILE A 235
LEU A 229
HIS A 194
SER A 103
 None
 0.82A 3r9vA-1m6jA:
undetectable
3r9vB-1m6jA:
undetectable		 3r9vA-1m6jA:
21.64
3r9vB-1m6jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		5 / 12 VAL A 240
PHE A 238
GLY A   9
VAL A  42
PRO A 223
 None
 1.28A 4bvaA-1m6jA:
undetectable		 4bvaA-1m6jA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		5 / 12 VAL A 240
PHE A 238
GLY A   9
VAL A  42
PRO A 223
 None
 1.31A 4bvaB-1m6jA:
undetectable		 4bvaB-1m6jA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1m6j TRIOSEPHOSPHATE
ISOMERASE
(Entamoeba
histolytica) 		3 / 3 GLU A 203
LYS A 199
ASN A 204
 None
 1.10A 4y1dA-1m6jA:
undetectable
4y1dD-1m6jA:
undetectable		 4y1dA-1m6jA:
22.05
4y1dD-1m6jA:
1.97