SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 4 HIS A 294
ALA A 293
PHE A 296
GLY A 295
 None
 1.12A 1mjoB-1m6sA:
undetectable		 1mjoB-1m6sA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.17A 2f162-1m6sA:
undetectable		 2f162-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.17A 2f16N-1m6sA:
undetectable		 2f16N-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 ASN A 136
THR A 137
ALA A 175
ASN A 174
VAL A 210
 None
 1.28A 2gl0A-1m6sA:
0.0
2gl0C-1m6sA:
1.0		 2gl0A-1m6sA:
21.33
2gl0C-1m6sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 ASN A 136
THR A 137
ALA A 175
ASN A 174
VAL A 210
 None
 1.30A 2gl0D-1m6sA:
0.0
2gl0E-1m6sA:
0.0		 2gl0D-1m6sA:
21.33
2gl0E-1m6sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 VAL A  64
SER A 192
VAL A 210
SER A  65
 None
 1.31A 2j9cA-1m6sA:
0.0
2j9cB-1m6sA:
undetectable
2j9cC-1m6sA:
0.0		 2j9cA-1m6sA:
16.43
2j9cB-1m6sA:
16.43
2j9cC-1m6sA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 8 ASP A  81
ASN A 107
GLY A 105
GLU A  79
 None
 1.07A 2ys6A-1m6sA:
2.4		 2ys6A-1m6sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 SER A  57
GLY A  58
THR A  59
 LLP  A 199 ( 3.9A)
LLP  A 199 ( 3.3A)
LLP  A 199 ( 3.5A)
 0.16A 3k9wA-1m6sA:
undetectable		 3k9wA-1m6sA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.20A 3mg0N-1m6sA:
undetectable		 3mg0N-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 PRO A 204
GLY A 240
ALA A 239
ALA A  23
 None
 0.83A 3ur0B-1m6sA:
1.1		 3ur0B-1m6sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 6 ASN A 136
GLY A 169
ASP A 168
ILE A  84
 None
None
LLP  A 199 ( 2.8A)
None
 0.99A 3w9tF-1m6sA:
0.0		 3w9tF-1m6sA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 ILE A  36
PHE A 195
LEU A 197
ALA A  43
ALA A  44
 None
 1.05A 4h1nA-1m6sA:
0.0		 4h1nA-1m6sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 8 ILE A 328
LEU A 306
ALA A 307
LEU A 300
 None
 0.72A 5y7pC-1m6sA:
undetectable		 5y7pC-1m6sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 8 ILE A 328
LEU A 306
ALA A 307
LEU A 300
 None
 0.72A 5y7pE-1m6sA:
undetectable		 5y7pE-1m6sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 VAL A 145
LEU A 201
ASP A   7
LEU A 251
SER A 179
 None
None
LLP  A 199 ( 3.7A)
None
None
 0.94A 6b0lB-1m6sA:
undetectable		 6b0lB-1m6sA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 SER A 192
SER A  65
GLY A  61
LEU A 131
 None
 0.76A 6btxA-1m6sA:
0.0		 6btxA-1m6sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 9 VAL A  76
HIS A 101
LEU A  95
ALA A  91
VAL A  89
 None
 1.22A 6c2mB-1m6sA:
undetectable		 6c2mB-1m6sA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 9 VAL A  76
HIS A 101
LEU A  95
VAL A  89
 None
 0.98A 6c2mD-1m6sA:
undetectable		 6c2mD-1m6sA:
12.88