SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 165
HIS A 276
ASP A 162
 None
 0.77A 1nw5A-1m6uA:
undetectable		 1nw5A-1m6uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 313
VAL A 150
TYR A 241
ILE A 246
PHE A 130
 None
 1.22A 1q6iA-1m6uA:
undetectable		 1q6iA-1m6uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 VAL A  78
LEU A 137
PHE A 130
SER A 240
 None
 0.98A 1wrlB-1m6uA:
undetectable		 1wrlB-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 200
LEU A 195
THR A 213
VAL A 249
THR A 219
 None
 1.14A 3dcjA-1m6uA:
undetectable
3dcjB-1m6uA:
undetectable		 3dcjA-1m6uA:
20.65
3dcjB-1m6uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 157
PHE A 273
PHE A 114
GLY A  98
PHE A  99
 None
None
None
SO4  A 400 (-3.1A)
None
 1.26A 3ko0A-1m6uA:
undetectable
3ko0C-1m6uA:
undetectable		 3ko0A-1m6uA:
16.09
3ko0C-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH201_1
(PROTEIN S100-A4)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 157
PHE A 273
PHE A 114
GLY A  98
PHE A  99
 None
None
None
SO4  A 400 (-3.1A)
None
 1.33A 3ko0H-1m6uA:
undetectable
3ko0I-1m6uA:
undetectable		 3ko0H-1m6uA:
16.09
3ko0I-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 114
GLY A  98
PHE A  99
ILE A 157
PHE A 273
 None
SO4  A 400 (-3.1A)
None
None
None
 1.45A 3ko0L-1m6uA:
undetectable
3ko0N-1m6uA:
undetectable		 3ko0L-1m6uA:
16.09
3ko0N-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 114
GLY A  98
PHE A  99
ILE A 157
PHE A 273
 None
SO4  A 400 (-3.1A)
None
None
None
 1.29A 3ko0O-1m6uA:
undetectable
3ko0Q-1m6uA:
undetectable		 3ko0O-1m6uA:
16.09
3ko0Q-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 157
PHE A 273
PHE A 114
GLY A  98
PHE A  99
 None
None
None
SO4  A 400 (-3.1A)
None
 1.33A 3ko0R-1m6uA:
undetectable
3ko0T-1m6uA:
undetectable		 3ko0R-1m6uA:
16.09
3ko0T-1m6uA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1m6u NDT80 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 310
PHE A 153
LEU A 279
LEU A 148
 None
 1.30A 5veuH-1m6uA:
undetectable		 5veuH-1m6uA:
22.06