SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1m76A:
undetectable		 1mz9C-1m76A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 LEU A  85
ALA A  31
GLY A  22
GLY A  23
ILE A  88
 None
None
NAD  A 350 ( 3.8A)
NAD  A 350 ( 4.5A)
None
 0.83A 1sdvA-1m76A:
0.0		 1sdvA-1m76A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 VAL A  20
ILE A  30
ALA A  34
VAL A  41
 None
 0.80A 2xrzB-1m76A:
2.4		 2xrzB-1m76A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ASN A 272
GLY A 204
ILE A 206
LYS A 200
ASP A 201
 None
 1.44A 3a25A-1m76A:
7.0		 3a25A-1m76A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 GLU A 230
TYR A 222
PHE A 247
TYR A 299
 None
 1.12A 3ku9B-1m76A:
3.5		 3ku9B-1m76A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 PHE A 298
SER A 278
SER A 280
 None
 0.91A 3ufgB-1m76A:
undetectable		 3ufgB-1m76A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 PHE A 154
THR A 174
ILE A 172
ASP A 201
 None
 0.94A 4pcuA-1m76A:
2.8		 4pcuA-1m76A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 LEU A 118
ILE A 108
ALA A 107
ALA A 133
 None
NAD  A 350 (-3.7A)
NAD  A 350 (-4.3A)
None
 0.70A 4zf8A-1m76A:
0.0		 4zf8A-1m76A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1m76 3-HYDROXYACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A  29
GLY A  27
GLY A  24
ALA A  36
LEU A  62
 None
None
NAD  A 350 (-3.1A)
None
None
 0.97A 5c0oF-1m76A:
7.3		 5c0oF-1m76A:
20.13