SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 8 LEU A   2
GLY A  30
HIS A  48
PHE A 106
 HEZ  A1002 (-4.0A)
CA  A1001 (-4.3A)
None
None
 0.69A 1sv9A-1m8tA:
18.1		 1sv9A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		5 / 7 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1001 (-4.3A)
None
CA  A1001 (-2.1A)
None
None
 0.58A 1th6A-1m8tA:
18.1		 1th6A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 7 GLY A  32
HIS A  48
TYR A  52
PRO A  68
 CA  A1001 (-4.2A)
None
None
None
 1.14A 1th6A-1m8tA:
18.1		 1th6A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		5 / 7 GLY A  30
HIS A  48
ASP A  49
TYR A  52
PRO A  68
 CA  A1001 (-4.3A)
None
CA  A1001 (-2.1A)
None
None
 0.59A 2armA-1m8tA:
18.1		 2armA-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		6 / 11 ILE A   9
ILE A  13
TYR A  25
GLY A  30
LEU A  41
PHE A 106
 None
None
None
CA  A1001 (-4.3A)
None
None
 0.41A 2azyA-1m8tA:
19.6		 2azyA-1m8tA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		5 / 11 ILE A  13
TYR A  25
GLY A  30
LEU A  41
TYR A 111
 None
None
CA  A1001 (-4.3A)
None
None
 0.74A 2azyA-1m8tA:
19.6		 2azyA-1m8tA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		5 / 10 LEU A   2
GLY A  30
HIS A  48
ASP A  49
PHE A 106
 HEZ  A1002 (-4.0A)
CA  A1001 (-4.3A)
None
CA  A1001 (-2.1A)
None
 0.63A 2b17A-1m8tA:
18.0		 2b17A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 6 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 HEZ  A1002 (-4.0A)
None
CA  A1001 (-2.1A)
None
 0.52A 2dpzA-1m8tA:
18.3		 2dpzA-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 5 LEU A   2
SER A  23
GLY A  30
HIS A  48
 HEZ  A1002 (-4.0A)
None
CA  A1001 (-4.3A)
None
 0.48A 2otfA-1m8tA:
18.3		 2otfA-1m8tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 8 LYS A   1
HIS A  48
ASP A  99
ALA A  55
 None
 1.29A 2rk8A-1m8tA:
2.0		 2rk8A-1m8tA:
10.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
CA  A1001 (-2.1A)
None
None
 0.50A 3fo7A-1m8tA:
18.2		 3fo7A-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		4 / 5 HIS A  48
ASP A  49
TYR A  52
PRO A  68
 None
CA  A1001 (-2.1A)
None
None
 0.46A 3h1xA-1m8tA:
18.2		 3h1xA-1m8tA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1m8t PHOSPHOLIPASE A2
(Ophiophagus
hannah) 		5 / 9 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 HEZ  A1002 (-4.0A)
None
None
CA  A1001 (-4.3A)
None
 0.36A 3oshA-1m8tA:
22.8		 3oshA-1m8tA:
67.23