SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 8 ASP A 103
TYR A 134
ARG A 140
TYR A 138
 None
 1.43A 1ceaA-1m9iA:
0.0
1ceaB-1m9iA:
undetectable		 1ceaA-1m9iA:
6.84
1ceaB-1m9iA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 6 TYR A 556
VAL A 574
ILE A 578
LEU A 504
 None
 1.27A 1j96A-1m9iA:
undetectable		 1j96A-1m9iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 12 ILE A 500
SER A 490
LEU A 504
LEU A 485
LYS A 483
 None
 1.44A 1lbcA-1m9iA:
undetectable
1lbcC-1m9iA:
undetectable		 1lbcA-1m9iA:
18.29
1lbcC-1m9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 ASP A 517
HIS A 558
ASP A 522
 None
 0.89A 1nw5A-1m9iA:
undetectable		 1nw5A-1m9iA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 8 TYR A 313
THR A 273
LEU A 260
MET A 278
 None
 1.49A 1uw6D-1m9iA:
undetectable
1uw6E-1m9iA:
undetectable		 1uw6D-1m9iA:
16.02
1uw6E-1m9iA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 8 TYR A 313
THR A 273
LEU A 260
MET A 278
 None
 1.46A 1uw6P-1m9iA:
undetectable
1uw6Q-1m9iA:
undetectable		 1uw6P-1m9iA:
16.02
1uw6Q-1m9iA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 12 PHE A 215
MET A 242
ILE A 230
ARG A 231
GLY A 204
 None
 1.22A 2lbdA-1m9iA:
0.0		 2lbdA-1m9iA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 SER A 628
ASP A 356
ASP A 633
 None
 0.73A 2plwA-1m9iA:
undetectable		 2plwA-1m9iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 6 LEU A 203
ILE A 226
ILE A 249
ARG A 250
 None
 0.92A 2q8hA-1m9iA:
undetectable		 2q8hA-1m9iA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 8 ILE A 461
TYR A 477
LEU A 489
LEU A 501
 None
 0.90A 2w98B-1m9iA:
undetectable		 2w98B-1m9iA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 ARG A 276
GLU A 100
SER A  13
 None
 0.90A 2xctD-1m9iA:
undetectable		 2xctD-1m9iA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 7 GLY A  88
ILE A  47
THR A  48
LEU A  85
 None
 0.80A 2xrhA-1m9iA:
0.3		 2xrhA-1m9iA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 THR A 577
SER A 542
LYS A 540
 None
 1.19A 3aocC-1m9iA:
0.0		 3aocC-1m9iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 353
ILE A 637
PRO A 601
LYS A 600
ARG A 465
 None
 1.33A 3bpxA-1m9iA:
0.0
3bpxB-1m9iA:
0.0		 3bpxA-1m9iA:
13.29
3bpxB-1m9iA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 SER A 490
LEU A 504
LEU A 485
LYS A 483
ILE A 500
 None
 1.41A 3h6tA-1m9iA:
undetectable
3h6tC-1m9iA:
undetectable		 3h6tA-1m9iA:
18.29
3h6tC-1m9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 ILE A 500
SER A 490
LEU A 504
LEU A 485
LYS A 483
 None
 1.40A 3h6tA-1m9iA:
undetectable
3h6tC-1m9iA:
undetectable		 3h6tA-1m9iA:
18.29
3h6tC-1m9iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 12 PHE A 215
MET A 242
ILE A 230
ARG A 231
GLY A 204
 None
 1.06A 3lbdA-1m9iA:
0.0		 3lbdA-1m9iA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 8 ASP A 180
TYR A 201
LEU A 203
LEU A 184
 None
 0.98A 3lm8A-1m9iA:
undetectable
3lm8C-1m9iA:
undetectable		 3lm8A-1m9iA:
15.36
3lm8C-1m9iA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 LYS A 607
ARG A 624
ASP A 585
 None
 1.08A 3o7wA-1m9iA:
undetectable		 3o7wA-1m9iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 ARG A 270
LYS A 262
LYS A 265
 CA  A 702 ( 4.4A)
None
None
 1.11A 4k50E-1m9iA:
0.0		 4k50E-1m9iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 ARG A 270
LYS A 262
LYS A 265
 CA  A 702 ( 4.4A)
None
None
 1.09A 4k50I-1m9iA:
0.0		 4k50I-1m9iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 12 LEU A 119
LEU A 115
ILE A 101
ASP A 145
LEU A 162
 None
 0.89A 4lmnA-1m9iA:
undetectable		 4lmnA-1m9iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 7 GLU A 460
LEU A 462
LEU A 501
LEU A 489
 None
 0.79A 4wg0B-1m9iA:
undetectable
4wg0C-1m9iA:
undetectable		 4wg0B-1m9iA:
1.98
4wg0C-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 444
GLU A 460
LEU A 462
LEU A 501
LEU A 489
 None
 0.89A 4wg0C-1m9iA:
undetectable
4wg0D-1m9iA:
undetectable
4wg0E-1m9iA:
undetectable		 4wg0C-1m9iA:
1.98
4wg0D-1m9iA:
1.98
4wg0E-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 444
GLU A 460
LEU A 462
LEU A 501
LEU A 489
 None
 0.88A 4wg0E-1m9iA:
undetectable
4wg0F-1m9iA:
undetectable
4wg0G-1m9iA:
undetectable		 4wg0E-1m9iA:
1.98
4wg0F-1m9iA:
1.98
4wg0G-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 501
LEU A 489
GLU A 460
LEU A 462
LEU A 444
 None
 1.23A 4wg0H-1m9iA:
undetectable
4wg0I-1m9iA:
undetectable
4wg0J-1m9iA:
undetectable		 4wg0H-1m9iA:
1.98
4wg0I-1m9iA:
1.98
4wg0J-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 444
GLU A 460
LEU A 462
LEU A 501
LEU A 489
 None
 0.89A 4wg0G-1m9iA:
undetectable
4wg0H-1m9iA:
undetectable
4wg0I-1m9iA:
undetectable		 4wg0G-1m9iA:
1.98
4wg0H-1m9iA:
1.98
4wg0I-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 11 LEU A 501
LEU A 489
GLU A 460
LEU A 462
LEU A 444
 None
 0.94A 4wg0J-1m9iA:
undetectable
4wg0K-1m9iA:
undetectable
4wg0L-1m9iA:
undetectable		 4wg0J-1m9iA:
1.98
4wg0K-1m9iA:
1.98
4wg0L-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 7 LEU A 501
LEU A 489
GLU A 460
LEU A 462
 None
 0.81A 4wg0L-1m9iA:
undetectable
4wg0M-1m9iA:
undetectable		 4wg0L-1m9iA:
1.98
4wg0M-1m9iA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 6 ASP A  69
ASP A  25
ASN A  23
GLN A  60
 None
 1.03A 5l6eA-1m9iA:
undetectable		 5l6eA-1m9iA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		5 / 8 ILE A 421
LEU A 417
ILE A 386
ILE A 387
SER A 630
 None
 1.05A 5numA-1m9iA:
undetectable		 5numA-1m9iA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 TYR A 481
HIS A 438
MET A 434
 None
 1.26A 6af6A-1m9iA:
0.0		 6af6A-1m9iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 5 GLU A 510
ASP A 522
HIS A 558
THR A 549
 None
 1.45A 6b58A-1m9iA:
0.0		 6b58A-1m9iA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 THR A 385
ALA A 375
LYS A 377
 None
 0.43A 6fgcA-1m9iA:
undetectable		 6fgcA-1m9iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		4 / 6 GLU A  57
ARG A  53
PHE A  17
PRO A  18
 None
 1.41A 6fgdA-1m9iA:
undetectable		 6fgdA-1m9iA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1m9i ANNEXIN VI
(Homo
sapiens) 		3 / 3 THR A 385
ALA A 375
LYS A 377
 None
 0.47A 6fgdA-1m9iA:
0.0		 6fgdA-1m9iA:
20.78