SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1m9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 LEU A 169
ASP A 189
LEU A 210
LEU A 188
 None
 0.95A 1e7cA-1m9sA:
undetectable		 1e7cA-1m9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 GLN A  95
LEU A 119
LEU A 103
LEU A 110
 None
 1.05A 1hk2A-1m9sA:
undetectable		 1hk2A-1m9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 LEU A 185
LEU A 182
VAL A 181
LEU A 138
HIS A 162
 None
 1.24A 1ie9A-1m9sA:
0.0		 1ie9A-1m9sA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 166
LEU A 138
LEU A 122
GLY A 123
 None
 0.85A 1n13D-1m9sA:
undetectable
1n13E-1m9sA:
undetectable		 1n13D-1m9sA:
11.38
1n13E-1m9sA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 ILE A  81
ILE A  88
LEU A 144
 None
 0.53A 2prgA-1m9sA:
undetectable		 2prgA-1m9sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		6 / 12 LEU A 110
ASN A 108
GLY A 107
ILE A  82
VAL A  91
ILE A  88
 None
 1.30A 3bvbA-1m9sA:
undetectable		 3bvbA-1m9sA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		6 / 12 LEU A 110
ASN A 108
GLY A 107
ILE A  82
VAL A  91
ILE A  88
 None
 1.24A 3bvbB-1m9sA:
undetectable		 3bvbB-1m9sA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 135
LEU A 204
VAL A 181
LEU A 169
 None
 0.68A 3g8iA-1m9sA:
undetectable		 3g8iA-1m9sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.07A 3hj3D-1m9sA:
undetectable		 3hj3D-1m9sA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 GLN A 240
SER A 216
LEU A 182
ILE A 220
 None
 1.09A 3ln1C-1m9sA:
undetectable		 3ln1C-1m9sA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 SER A 192
GLY A 172
SER A 216
 None
 0.62A 3loqA-1m9sA:
undetectable		 3loqA-1m9sA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 PRO A 164
LEU A 188
ASP A 189
LYS A 209
 None
 1.09A 3lsfH-1m9sA:
undetectable		 3lsfH-1m9sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 LEU A 119
LEU A 122
LEU A 144
ILE A  94
 None
 0.76A 4klaA-1m9sA:
undetectable		 4klaA-1m9sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.80A 4wg0B-1m9sA:
undetectable
4wg0C-1m9sA:
undetectable
4wg0D-1m9sA:
undetectable		 4wg0B-1m9sA:
2.49
4wg0C-1m9sA:
2.49
4wg0D-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.68A 4wg0B-1m9sA:
undetectable
4wg0C-1m9sA:
undetectable		 4wg0B-1m9sA:
2.49
4wg0C-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.78A 4wg0D-1m9sA:
undetectable
4wg0E-1m9sA:
undetectable
4wg0F-1m9sA:
undetectable		 4wg0D-1m9sA:
2.49
4wg0E-1m9sA:
2.49
4wg0F-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.80A 4wg0C-1m9sA:
undetectable
4wg0D-1m9sA:
undetectable
4wg0E-1m9sA:
undetectable		 4wg0C-1m9sA:
2.49
4wg0D-1m9sA:
2.49
4wg0E-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.76A 4wg0F-1m9sA:
undetectable
4wg0G-1m9sA:
undetectable
4wg0H-1m9sA:
undetectable		 4wg0F-1m9sA:
2.49
4wg0G-1m9sA:
2.49
4wg0H-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.78A 4wg0E-1m9sA:
undetectable
4wg0F-1m9sA:
undetectable
4wg0G-1m9sA:
undetectable		 4wg0E-1m9sA:
2.49
4wg0F-1m9sA:
2.49
4wg0G-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.77A 4wg0H-1m9sA:
undetectable
4wg0I-1m9sA:
undetectable
4wg0J-1m9sA:
undetectable		 4wg0H-1m9sA:
2.49
4wg0I-1m9sA:
2.49
4wg0J-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.77A 4wg0G-1m9sA:
undetectable
4wg0H-1m9sA:
undetectable
4wg0I-1m9sA:
undetectable		 4wg0G-1m9sA:
2.49
4wg0H-1m9sA:
2.49
4wg0I-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.78A 4wg0J-1m9sA:
undetectable
4wg0K-1m9sA:
undetectable
4wg0L-1m9sA:
undetectable		 4wg0J-1m9sA:
2.49
4wg0K-1m9sA:
2.49
4wg0L-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.74A 4wg0I-1m9sA:
undetectable
4wg0J-1m9sA:
undetectable
4wg0K-1m9sA:
undetectable		 4wg0I-1m9sA:
2.49
4wg0J-1m9sA:
2.49
4wg0K-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 ASN A 261
LEU A 223
LEU A 226
LEU A 237
 None
 0.68A 4wg0L-1m9sA:
undetectable
4wg0M-1m9sA:
undetectable		 4wg0L-1m9sA:
2.49
4wg0M-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.73A 4wg0K-1m9sA:
undetectable
4wg0L-1m9sA:
undetectable
4wg0M-1m9sA:
undetectable		 4wg0K-1m9sA:
2.49
4wg0L-1m9sA:
2.49
4wg0M-1m9sA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 ASN A 130
LEU A 116
PHE A 126
 None
 0.70A 5dsgA-1m9sA:
undetectable		 5dsgA-1m9sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 LEU A 110
ASN A 108
ILE A  82
VAL A  91
ILE A  88
 None
 1.10A 5kqyA-1m9sA:
undetectable		 5kqyA-1m9sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 10 LEU A 110
ASN A 108
ILE A  82
VAL A  91
ILE A  88
 None
 1.03A 5kr1A-1m9sA:
undetectable		 5kr1A-1m9sA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 110
ASN A 108
ILE A  82
VAL A  91
ILE A  88
 None
 1.09A 5kr2B-1m9sA:
undetectable		 5kr2B-1m9sA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 9 LEU A 110
ASN A 108
ILE A  82
VAL A  91
ILE A  88
 None
 1.08A 5kr2D-1m9sA:
undetectable		 5kr2D-1m9sA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.66A 5qgjA-1m9sA:
0.0		 5qgjA-1m9sA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.65A 5qgmA-1m9sA:
0.0		 5qgmA-1m9sA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.71A 5qh9A-1m9sA:
undetectable		 5qh9A-1m9sA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 ILE A 220
VAL A 202
LEU A 237
LEU A 213
LEU A 235
 None
 1.28A 5tiwA-1m9sA:
undetectable		 5tiwA-1m9sA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 ASP A 541
ILE A 524
ARG A 543
TYR A 472
 None
 1.20A 6hisA-1m9sA:
0.0
6hisB-1m9sA:
undetectable		 6hisA-1m9sA:
11.21
6hisB-1m9sA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 ASP A 541
ILE A 524
ARG A 543
TYR A 472
 None
 1.21A 6hisB-1m9sA:
undetectable
6hisC-1m9sA:
undetectable		 6hisB-1m9sA:
11.21
6hisC-1m9sA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 ASP A 541
ILE A 524
ARG A 543
TYR A 472
 None
 1.21A 6hisC-1m9sA:
undetectable
6hisD-1m9sA:
undetectable		 6hisC-1m9sA:
11.21
6hisD-1m9sA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 ASP A 541
ILE A 524
ARG A 543
TYR A 472
 None
 1.20A 6hisD-1m9sA:
undetectable
6hisE-1m9sA:
undetectable		 6hisD-1m9sA:
11.21
6hisE-1m9sA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1m9s INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 TYR A 472
ASP A 541
ILE A 524
ARG A 543
 None
 1.22A 6hisA-1m9sA:
undetectable
6hisE-1m9sA:
undetectable		 6hisA-1m9sA:
11.21
6hisE-1m9sA:
11.21