SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1c9sU-1macA:
undetectable
1c9sV-1macA:
undetectable		 1c9sU-1macA:
17.79
1c9sV-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 7 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.81A 1gtnA-1macA:
undetectable
1gtnK-1macA:
undetectable		 1gtnA-1macA:
17.79
1gtnK-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 SER A 139
ALA A  80
THR A 113
ILE A  85
 None
 0.79A 1gtnA-1macA:
undetectable
1gtnB-1macA:
undetectable		 1gtnA-1macA:
17.79
1gtnB-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 SER A 139
ALA A  80
THR A 113
ILE A  85
 None
 0.80A 1gtnE-1macA:
undetectable
1gtnF-1macA:
undetectable		 1gtnE-1macA:
17.79
1gtnF-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.81A 1gtnP-1macA:
undetectable
1gtnQ-1macA:
0.9		 1gtnP-1macA:
17.79
1gtnQ-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 TRP A  32
PHE A  28
TRP A 182
 None
 1.42A 1r15C-1macA:
undetectable		 1r15C-1macA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 TRP A  32
PHE A  28
TRP A 182
 None
 1.42A 1r15F-1macA:
undetectable		 1r15F-1macA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 TRP A  32
PHE A  28
TRP A 182
 None
 1.42A 1r15G-1macA:
undetectable		 1r15G-1macA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 TRP A  32
PHE A  28
TRP A 182
 None
 1.42A 1r15H-1macA:
undetectable		 1r15H-1macA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1utdB-1macA:
undetectable
1utdC-1macA:
undetectable		 1utdB-1macA:
17.79
1utdC-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1utdF-1macA:
undetectable
1utdG-1macA:
undetectable		 1utdF-1macA:
17.79
1utdG-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.81A 1utdI-1macA:
undetectable
1utdJ-1macA:
undetectable		 1utdI-1macA:
17.79
1utdJ-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 8 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.80A 1utdJ-1macA:
undetectable
1utdK-1macA:
undetectable		 1utdJ-1macA:
17.79
1utdK-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 5 PHE A 118
THR A 114
PHE A 108
ILE A 132
 None
 1.17A 4jx1E-1macA:
0.0		 4jx1E-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 5 GLY A 141
SER A 139
ALA A 138
PHE A 142
 None
 1.00A 4m93B-1macA:
undetectable
4m93C-1macA:
undetectable		 4m93B-1macA:
22.35
4m93C-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		5 / 12 LEU A 109
ASP A 189
ASP A 188
TYR A 194
GLY A 184
 None
 1.14A 4qb9E-1macA:
undetectable		 4qb9E-1macA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 4 ASN A 180
TRP A 182
LEU A 191
PHE A 108
 None
 1.36A 4u15B-1macA:
undetectable		 4u15B-1macA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 PHE A 147
ILE A 106
ASP A 159
 None
 0.69A 5cswA-1macA:
undetectable		 5cswA-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		3 / 3 PHE A 147
ILE A 106
ASP A 159
 None
 0.66A 5cswB-1macA:
undetectable		 5cswB-1macA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE
(Paenibacillus
macerans) 		4 / 6 THR A  83
TYR A 194
GLY A 192
ASN A 195
 None
 0.89A 5k4pA-1macA:
undetectable		 5k4pA-1macA:
18.95