SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		7 / 8 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.46A 1aq7A-1mbqA:
40.6		 1aq7A-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.34A 1bcuH-1mbqA:
18.2		 1bcuH-1mbqA:
37.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.4A)
 0.34A 1dwcH-1mbqA:
33.7		 1dwcH-1mbqA:
37.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 9 LEU A 105
ILE A 106
LEU A 209
VAL A  31
GLY A  44
 None
 1.25A 1e7aB-1mbqA:
undetectable		 1e7aB-1mbqA:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.42A 1etrH-1mbqA:
33.6		 1etrH-1mbqA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.36A 1f5lA-1mbqA:
16.5		 1f5lA-1mbqA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 8 SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
None
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.51A 1f5lA-1mbqA:
16.5		 1f5lA-1mbqA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.26A 1tnlA-1mbqA:
41.0		 1tnlA-1mbqA:
65.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 5 LEU A 155
ILE A  73
SER A  32
GLY A  43
HIS A  29
 None
 1.08A 2otfA-1mbqA:
undetectable		 2otfA-1mbqA:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.23A 2otvA-1mbqA:
41.1		 2otvA-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1mbq TRYPSIN
(Oncorhynchus
keta) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
None
 0.36A 2p16A-1mbqA:
35.0		 2p16A-1mbqA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		7 / 8 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
None
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.41A 2vinA-1mbqA:
17.4		 2vinA-1mbqA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
None
BEN  A1222 (-3.4A)
None
 0.42A 2w26A-1mbqA:
14.4		 2w26A-1mbqA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		7 / 11 HIS A  57
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.34A 3gy3A-1mbqA:
39.9		 3gy3A-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.30A 3rxfA-1mbqA:
41.2		 3rxfA-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.4A)
 0.30A 3rxhA-1mbqA:
41.2		 3rxhA-1mbqA:
65.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.93A 4dubA-1mbqA:
0.0		 4dubA-1mbqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.88A 4dubB-1mbqA:
undetectable		 4dubB-1mbqA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 9 GLY A  44
VAL A  31
PRO A 198
PRO A 124
GLU A 204
 None
 1.43A 4fimA-1mbqA:
undetectable		 4fimA-1mbqA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
None
None
BEN  A1222 (-3.5A)
 0.60A 4fu8A-1mbqA:
33.9		 4fu8A-1mbqA:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 None
BEN  A1222 (-2.9A)
None
None
BEN  A1222 (-3.4A)
 0.28A 4hfpD-1mbqA:
33.6		 4hfpD-1mbqA:
37.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 0.98A 4qdjA-1mbqA:
undetectable		 4qdjA-1mbqA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.33A 4rn6B-1mbqA:
28.3		 4rn6B-1mbqA:
37.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		5 / 9 VAL A  47
LEU A  46
SER A  45
LEU A 209
LEU A 238
 None
 1.02A 4rs0A-1mbqA:
undetectable		 4rs0A-1mbqA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		3 / 3 TYR A 217
SER A 171
TRP A 215
 None
 0.96A 5n8jB-1mbqA:
undetectable		 5n8jB-1mbqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		3 / 3 TYR A 217
SER A 171
TRP A 215
 None
 0.92A 5n8jA-1mbqA:
undetectable		 5n8jA-1mbqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		3 / 3 TYR A 217
SER A 171
TRP A 215
 None
 0.92A 5n8jD-1mbqA:
undetectable		 5n8jD-1mbqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1mbq TRYPSIN
(Oncorhynchus
keta) 		4 / 8 GLN A 156
VAL A  17
ALA A 221
TYR A1184
 None
 0.92A 6cduD-1mbqA:
undetectable
6cduE-1mbqA:
undetectable		 6cduD-1mbqA:
20.72
6cduE-1mbqA:
20.72