SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 11 ALA A  91
LEU A  30
THR A  81
PRO A  80
VAL A  27
 None
 1.11A 1rv7A-1mbxA:
undetectable
1rv7B-1mbxA:
undetectable		 1rv7A-1mbxA:
20.71
1rv7B-1mbxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		4 / 6 ALA A  40
SER A  39
THR A 104
ASN A   3
 None
 0.98A 1yvpB-1mbxA:
undetectable		 1yvpB-1mbxA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		4 / 6 GLN A  56
LEU A  58
GLU A  59
LEU A  32
 None
 0.79A 3h5gA-1mbxA:
undetectable
3h5gC-1mbxA:
undetectable		 3h5gA-1mbxA:
11.89
3h5gC-1mbxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 12 SER A  83
THR A  81
ALA A 120
LEU A 124
LEU A  30
 None
 1.24A 3lcvB-1mbxA:
undetectable		 3lcvB-1mbxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 11 LEU A  35
LEU A  31
GLU A  42
LEU A  44
LEU A 109
 None
None
YBT  A 211 (-2.4A)
None
None
 1.22A 4wg0H-1mbxA:
undetectable
4wg0I-1mbxA:
undetectable
4wg0J-1mbxA:
undetectable		 4wg0H-1mbxA:
8.21
4wg0I-1mbxA:
8.21
4wg0J-1mbxA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 11 LEU A 109
GLU A  42
LEU A  44
LEU A  35
LEU A  31
 None
YBT  A 211 (-2.4A)
None
None
None
 1.13A 4wg0K-1mbxA:
undetectable
4wg0L-1mbxA:
undetectable
4wg0M-1mbxA:
undetectable		 4wg0K-1mbxA:
8.21
4wg0L-1mbxA:
8.21
4wg0M-1mbxA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 12 LEU A 109
ARG A 131
SER A 118
GLU A  28
LEU A  44
 None
 1.35A 5czyA-1mbxA:
undetectable		 5czyA-1mbxA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 8 ALA A  43
LEU A  31
LEU A 124
LEU A  51
LEU A  35
 None
 1.43A 5jqbA-1mbxA:
undetectable
5jqbB-1mbxA:
undetectable		 5jqbA-1mbxA:
17.34
5jqbB-1mbxA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A
(Escherichia
coli) 		5 / 8 ALA A  91
LEU A  30
LEU A  34
LEU A   2
LEU A  10
 None
 1.08A 5jqbA-1mbxA:
undetectable
5jqbB-1mbxA:
undetectable		 5jqbA-1mbxA:
17.34
5jqbB-1mbxA:
22.67