SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GX9_A_REAA1163_1 (BETA-LACTOGLOBULIN)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 11	LEU A 513 VAL A 514 ILE A 458 VAL A 510 PHE A 426	None None PCG A 160 (-3.6A) None None	1.19A	1gx9A-1mc0A: 0.0	1gx9A-1mc0A: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRK_D_CAMD502_0 (CAMPHOR 5-MONOOXYGENASE)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	4 / 5	PHE A 363 LEU A 242 THR A 249 VAL A 358	None	0.98A	3wrkD-1mc0A: 0.0	3wrkD-1mc0A: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_C_ECNC403_1 (FLAVOHEMOGLOBIN)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 9	ILE A 500 LEU A 407 VAL A 403 VAL A 434 LEU A 427	None	1.23A	4g1bC-1mc0A: 2.1	4g1bC-1mc0A: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_A_NPSA603_1 (SERUM ALBUMIN)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 11	LEU A 289 ARG A 288 LEU A 301 LEU A 339 LEU A 312	None	1.39A	4or0A-1mc0A: 0.0	4or0A-1mc0A: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QZU_D_ACTD201_0 (RETINOL-BINDING PROTEIN 2)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	3 / 3	ASP A 219 HIS A 361 LYS A 221	None	0.96A	4qzuD-1mc0A: 0.6	4qzuD-1mc0A: 15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AJQ_B_DB8B800_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 10	ILE A 452 GLY A 509 LEU A 428 ALA A 454 ASP A 455	None	1.46A	5ajqB-1mc0A: undetectable	5ajqB-1mc0A: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4U_C_SAMC301_0 (UNCHARACTERIZED PROTEIN MJ0489)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 12	ILE A 410 LEU A 406 GLY A 538 ILE A 541 GLY A 466	None	0.82A	5d4uC-1mc0A: undetectable	5d4uC-1mc0A: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4U_D_SAMD301_0 (UNCHARACTERIZED PROTEIN MJ0489)	1mc0	3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A (Mus musculus)	5 / 12	ILE A 410 LEU A 406 GLY A 538 ILE A 541 GLY A 466	None	0.80A	5d4uD-1mc0A: undetectable	5d4uD-1mc0A: 21.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GX9_A_REAA1163_1","BETA-LACTOGLOBULIN","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"LEU A 513;VAL A 514;ILE A 458;VAL A 510;PHE A 426","None;None;PCG A 160 (-3.6A);None;None","1.19A","1gx9A-1mc0A:0.0","1gx9A-1mc0A:19.94"],["3WRK_D_CAMD502_0","CAMPHOR 5-MONOOXYGENASE","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",4,"PHE A 363;LEU A 242;THR A 249;VAL A 358","None","0.98A","3wrkD-1mc0A:0.0","3wrkD-1mc0A:23.21"],["4G1B_C_ECNC403_1","FLAVOHEMOGLOBIN","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"ILE A 500;LEU A 407;VAL A 403;VAL A 434;LEU A 427","None","1.23A","4g1bC-1mc0A:2.1","4g1bC-1mc0A:21.97"],["4OR0_A_NPSA603_1","SERUM ALBUMIN","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"LEU A 289;ARG A 288;LEU A 301;LEU A 339;LEU A 312","None","1.39A","4or0A-1mc0A:0.0","4or0A-1mc0A:22.73"],["4QZU_D_ACTD201_0","RETINOL-BINDING PROTEIN 2","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",3,"ASP A 219;HIS A 361;LYS A 221","None","0.96A","4qzuD-1mc0A:0.6","4qzuD-1mc0A:15.45"],["5AJQ_B_DB8B800_1","SERINE\/THREONINE-PROTEIN KINASE 10","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"ILE A 452;GLY A 509;LEU A 428;ALA A 454;ASP A 455","None","1.46A","5ajqB-1mc0A:undetectable","5ajqB-1mc0A:22.93"],["5D4U_C_SAMC301_0","UNCHARACTERIZED PROTEIN MJ0489","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"ILE A 410;LEU A 406;GLY A 538;ILE A 541;GLY A 466","None","0.82A","5d4uC-1mc0A:undetectable","5d4uC-1mc0A:21.39"],["5D4U_D_SAMD301_0","UNCHARACTERIZED PROTEIN MJ0489","1mc0","3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A","Mus musculus",5,"ILE A 410;LEU A 406;GLY A 538;ILE A 541;GLY A 466","None","0.80A","5d4uD-1mc0A:undetectable","5d4uD-1mc0A:21.39"]]