SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 8 GLY A1035
GLY A1030
ARG A1034
GLY A1032
 None
IPA  A1135 ( 4.4A)
None
None
 0.72A 1jhqA-1mc2A:
undetectable		 1jhqA-1mc2A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 5 GLU A1108
THR A1013
LEU A1106
LEU A1110
 None
 1.18A 1u18B-1mc2A:
0.0		 1u18B-1mc2A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 12 LEU A1002
GLY A1023
ARG A1034
TYR A1052
LYS A1069
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
None
None
None
 0.83A 1y4lA-1mc2A:
23.8		 1y4lA-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		8 / 12 LEU A1002
GLY A1023
GLY A1030
GLY A1033
ARG A1034
LYS A1049
TYR A1052
LYS A1070
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
None
None
 0.62A 1y4lA-1mc2A:
23.8		 1y4lA-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 11 LEU A1002
LEU A1005
GLY A1032
HIS A1048
TYR A1052
LYS A1070
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.82A 1y4lB-1mc2A:
23.1		 1y4lB-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		9 / 11 LEU A1002
LEU A1005
VAL A1031
GLY A1033
ARG A1034
HIS A1048
LYS A1049
TYR A1052
LYS A1070
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
None
None
None
 0.57A 1y4lB-1mc2A:
23.1		 1y4lB-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 11 LEU A1005
ARG A1034
HIS A1048
TYR A1052
LYS A1053
 IPA  A1135 ( 4.2A)
None
None
None
None
 1.29A 1y4lB-1mc2A:
23.1		 1y4lB-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 9 GLY A1006
LYS A1007
PRO A1017
LYS A1069
ARG A1072
 IPA  A1136 (-3.6A)
None
IPA  A1136 (-4.4A)
None
None
 1.29A 3bjwG-1mc2A:
20.0		 3bjwG-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 7 LYS A1007
GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 0.90A 3bjwB-1mc2A:
21.2		 3bjwB-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 10 GLU A1004
GLY A1006
PRO A1017
LYS A1069
ARG A1072
 None
IPA  A1136 (-3.6A)
IPA  A1136 (-4.4A)
None
None
 1.15A 3bjwD-1mc2A:
19.9		 3bjwD-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 6 GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 0.27A 3bjwE-1mc2A:
21.0		 3bjwE-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 7 LYS A1007
GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 1.09A 3bjwF-1mc2A:
21.3		 3bjwF-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 8 GLY A1006
LYS A1007
PRO A1017
ARG A1072
 IPA  A1136 (-3.6A)
None
IPA  A1136 (-4.4A)
None
 0.96A 3bjwA-1mc2A:
20.1		 3bjwA-1mc2A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 7 GLN A1011
GLY A1014
ARG A1107
LEU A1110
 None
 0.23A 3bjwH-1mc2A:
21.1		 3bjwH-1mc2A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		3 / 3 LEU A1110
GLU A1012
ILE A1009
 None
 0.56A 3czhA-1mc2A:
0.0		 3czhA-1mc2A:
13.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 6 LYS A1007
ASN A1016
PRO A1017
ARG A1072
 None
None
IPA  A1136 (-4.4A)
None
 0.67A 4yv5B-1mc2A:
24.2		 4yv5B-1mc2A:
77.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		4 / 6 LYS A1007
ASN A1016
PRO A1017
ARG A1072
 None
None
IPA  A1136 (-4.4A)
None
 0.63A 4yv5A-1mc2A:
23.9		 4yv5A-1mc2A:
77.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_1
()		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 8 LEU A1002
LEU A1005
GLY A1033
ARG A1034
LYS A1049
TYR A1052
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.78A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_1
()		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 8 LEU A1002
LEU A1005
GLY A1033
LYS A1049
TYR A1052
LYS A1069
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.64A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_2
(-)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 12 LEU A1002
GLY A1023
GLY A1030
GLY A1033
ARG A1034
LYS A1049
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
 1.27A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_2
(-)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		5 / 12 LEU A1002
GLY A1023
GLY A1030
GLY A1033
LYS A1049
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
 0.94A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_2
(-)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 12 LEU A1002
LEU A1005
GLY A1023
GLY A1030
GLY A1033
TYR A1052
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
 0.88A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CE2_B_SVRB202_2
(-)		 1mc2 ACUTOHAEMONLYSIN
(Deinagkistrodon
acutus) 		6 / 12 LEU A1005
GLY A1023
GLY A1030
GLY A1033
ARG A1034
TYR A1052
 IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
 0.54A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13