SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		3 / 3 LEU A 212
VAL A 215
LEU A 219
 None
 0.53A 1mz9B-1mc8A:
undetectable		 1mz9B-1mc8A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 ILE A 326
GLY A 143
LEU A  61
PRO A  75
ILE A  26
 None
 1.26A 1zq9A-1mc8A:
undetectable		 1zq9A-1mc8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 5 GLN A 156
ALA A 149
GLN A 148
ILE A 147
 None
 1.43A 2z0aA-1mc8A:
undetectable		 2z0aA-1mc8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.93A 3abkA-1mc8A:
undetectable
3abkJ-1mc8A:
0.0		 3abkA-1mc8A:
20.59
3abkJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 7 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 1.00A 3ag2N-1mc8A:
0.0
3ag2W-1mc8A:
0.0		 3ag2N-1mc8A:
20.59
3ag2W-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ARG A  88
VAL A 270
TYR A 273
ILE A 275
 None
 1.03A 3remA-1mc8A:
undetectable		 3remA-1mc8A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ARG A  88
VAL A 270
TYR A 273
ILE A 275
 None
 1.02A 3remB-1mc8A:
undetectable		 3remB-1mc8A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 6 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.89A 3wg7A-1mc8A:
0.0
3wg7J-1mc8A:
0.0		 3wg7A-1mc8A:
20.59
3wg7J-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 6 GLU A 116
ASP A 173
GLU A 154
ARG A 186
 None
 1.39A 4ntxA-1mc8A:
0.0
4ntxC-1mc8A:
undetectable		 4ntxA-1mc8A:
23.13
4ntxC-1mc8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 7 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.85A 5b1aA-1mc8A:
0.0
5b1aJ-1mc8A:
undetectable		 5b1aA-1mc8A:
20.59
5b1aJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 6 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 1.01A 5b1aN-1mc8A:
0.0
5b1aW-1mc8A:
0.0		 5b1aN-1mc8A:
20.59
5b1aW-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 7 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.85A 5b3sA-1mc8A:
0.0
5b3sJ-1mc8A:
undetectable		 5b3sA-1mc8A:
20.59
5b3sJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 GLU A 133
LEU A 139
LEU A  29
ILE A  32
ALA A  31
 None
 0.93A 5j7wC-1mc8A:
0.0		 5j7wC-1mc8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 GLU A 133
LEU A 139
LEU A  29
ILE A  32
ALA A  31
 None
 1.00A 5j7wD-1mc8A:
0.0		 5j7wD-1mc8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 GLY A 244
GLY A   6
ILE A   5
GLY A 240
GLY A 241
 None
 0.90A 5koxA-1mc8A:
undetectable		 5koxA-1mc8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 GLY A 244
GLY A   6
ILE A   5
THR A 235
GLY A 241
 None
 0.92A 5koxA-1mc8A:
undetectable		 5koxA-1mc8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ILE A  73
LEU A  19
ILE A  24
ILE A  26
 None
 0.72A 5numA-1mc8A:
undetectable		 5numA-1mc8A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.80A 5zcoA-1mc8A:
0.0
5zcoJ-1mc8A:
0.0		 5zcoA-1mc8A:
20.59
5zcoJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 7 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.82A 5zcpA-1mc8A:
0.0
5zcpJ-1mc8A:
undetectable		 5zcpA-1mc8A:
20.59
5zcpJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 7 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.84A 5zcqA-1mc8A:
0.0
5zcqJ-1mc8A:
undetectable		 5zcqA-1mc8A:
20.59
5zcqJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 8 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.90A 5zcqN-1mc8A:
0.0
5zcqW-1mc8A:
undetectable		 5zcqN-1mc8A:
20.59
5zcqW-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		5 / 12 GLY A 192
VAL A 201
ILE A  26
PHE A  35
ALA A  31
 None
 1.03A 6c2mD-1mc8A:
undetectable		 6c2mD-1mc8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 6 PRO A 145
ILE A 326
GLY A 143
GLU A 294
 None
 1.06A 6gqiA-1mc8A:
undetectable		 6gqiA-1mc8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mc8 FLAP ENDONUCLEASE-1
(Pyrococcus
horikoshii) 		4 / 6 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.71A 6nmfN-1mc8A:
0.0
6nmfW-1mc8A:
0.0		 6nmfN-1mc8A:
20.59
6nmfW-1mc8A:
10.20