SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 LYS H  66
TYR H  60
PRO H  63
 None
 1.27A 2j9cC-1mcoH:
0.0		 2j9cC-1mcoH:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 12 PRO H 328
PHE H 389
GLY H 356
LEU H 391
VAL H 354
 None
 1.15A 2zifA-1mcoH:
undetectable		 2zifA-1mcoH:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 8 SER H 385
VAL H 354
LEU H 391
PRO H 381
 None
 1.15A 3jq7C-1mcoH:
undetectable		 3jq7C-1mcoH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 TYR H  54
LEU H  65
LYS H  66
 None
 0.73A 3sueD-1mcoH:
undetectable		 3sueD-1mcoH:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 GLU H 367
GLY H 370
SER H 409
 None
 0.61A 4b53B-1mcoH:
5.7		 4b53B-1mcoH:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 7 ILE H  50
VAL H  94
SER H  37
PHE H  80
 None
 1.29A 4iarA-1mcoH:
undetectable		 4iarA-1mcoH:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		5 / 11 ASP H 265
VAL H 264
VAL H 269
LEU H 291
THR H 292
 None
None
None
None
SIA  H 436 (-4.0A)
 1.42A 4yhaC-1mcoH:
undetectable		 4yhaC-1mcoH:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 6 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.07A 5igiA-1mcoH:
undetectable		 5igiA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		4 / 5 PRO H 229
HIS H 420
LEU H 391
TYR H 358
 GAL  H 435 (-4.8A)
None
None
None
 1.06A 5igjA-1mcoH:
undetectable		 5igjA-1mcoH:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 LYS H 323
GLN H 296
ASN H 297
 None
 0.84A 5l2tA-1mcoH:
undetectable		 5l2tA-1mcoH:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 THR H 379
PRO H 331
ARG H 329
 None
 0.85A 5nd7B-1mcoH:
undetectable		 5nd7B-1mcoH:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens) 		3 / 3 PRO H 189
SER H 191
SER H 192
 None
 0.65A 6bpyA-1mcoH:
undetectable		 6bpyA-1mcoH:
21.86