SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 11 GLY W  12
VAL W 107
GLU W  85
ILE W  18
HIS W 201
 None
 1.35A 1vhwA-1mcwW:
undetectable
1vhwD-1mcwW:
undetectable		 1vhwA-1mcwW:
22.88
1vhwD-1mcwW:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 11 GLY W  12
VAL W 107
GLU W  85
ILE W  18
HIS W 201
 None
 1.38A 1vhwC-1mcwW:
undetectable
1vhwE-1mcwW:
undetectable		 1vhwC-1mcwW:
22.88
1vhwE-1mcwW:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 11 HIS W 201
GLY W  12
VAL W 107
GLU W  85
ILE W  18
 None
 1.38A 1vhwA-1mcwW:
undetectable
1vhwD-1mcwW:
undetectable		 1vhwA-1mcwW:
22.88
1vhwD-1mcwW:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		5 / 11 HIS W 201
GLY W  12
VAL W 107
GLU W  85
ILE W  18
 None
 1.35A 1vhwC-1mcwW:
undetectable
1vhwE-1mcwW:
undetectable		 1vhwC-1mcwW:
22.88
1vhwE-1mcwW:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 6 SER W  74
ALA W  73
SER W  67
THR W  19
 None
 1.21A 1yvpB-1mcwW:
undetectable		 1yvpB-1mcwW:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 6 LEU W 182
ALA W 134
HIS W 192
ASP W 155
 None
 1.22A 2dpzA-1mcwW:
undetectable		 2dpzA-1mcwW:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 7 SER W  36
TYR W  51
PRO W  57
PHE W  99
 None
 1.13A 5aclA-1mcwW:
17.1		 5aclA-1mcwW:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 4 VAL W 107
GLU W  85
GLY W  12
LEU W  80
 None
 1.26A 5g5gC-1mcwW:
0.0		 5g5gC-1mcwW:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens) 		4 / 6 SER W  21
GLY W  70
ASN W  71
ILE W  35
 None
 1.07A 5j4nA-1mcwW:
undetectable		 5j4nA-1mcwW:
17.22