SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1md7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 8 LYS A 382
THR A 380
ALA A 383
VAL A 378
 None
 0.85A 1sn5C-1md7A:
undetectable		 1sn5C-1md7A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.14A 1yatA-1md7A:
undetectable		 1yatA-1md7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 12 LEU A 561
LEU A 475
LEU A 543
ALA A 542
ILE A 541
 None
 1.21A 2bxpA-1md7A:
undetectable		 2bxpA-1md7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 10 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.13A 3ihzA-1md7A:
undetectable		 3ihzA-1md7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 11 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.05A 3o5rA-1md7A:
undetectable		 3o5rA-1md7A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 8 GLY A 638
ALA A 637
ASP A 636
GLY A 468
ILE A 466
 None
 1.13A 3so9A-1md7A:
0.7		 3so9A-1md7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 10 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.26A 3uqaA-1md7A:
undetectable		 3uqaA-1md7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 8 GLY A 639
GLY A 638
ILE A 541
LEU A 543
VAL A 673
 None
 1.11A 3v1nA-1md7A:
undetectable		 3v1nA-1md7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_1
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 10 TRP A 659
ASN A 536
TYR A 676
PHE A 669
TYR A 670
 None
 1.07A 3zoaA-1md7A:
0.0		 3zoaA-1md7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.43A 4f3tA-1md7A:
0.0		 4f3tA-1md7A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 12 GLY A 472
GLN A 461
VAL A 576
ILE A 541
VAL A 673
 None
 1.34A 4okwA-1md7A:
undetectable		 4okwA-1md7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 12 VAL A 673
GLY A 472
ILE A 541
LEU A 543
LEU A 474
 None
 1.05A 4qdjA-1md7A:
undetectable		 4qdjA-1md7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		6 / 10 ALA A 483
THR A 482
ALA A 542
ALA A 484
GLY A 655
THR A 671
 None
 1.49A 4qvyK-1md7A:
undetectable
4qvyL-1md7A:
undetectable		 4qvyK-1md7A:
21.98
4qvyL-1md7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		6 / 10 ALA A 483
THR A 482
ALA A 542
ALA A 484
GLY A 655
THR A 671
 None
 1.49A 4qvyY-1md7A:
undetectable
4qvyZ-1md7A:
undetectable		 4qvyY-1md7A:
21.98
4qvyZ-1md7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.38A 4w5qA-1md7A:
0.0		 4w5qA-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.43A 4w5rA-1md7A:
0.0		 4w5rA-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.44A 4w5tA-1md7A:
0.0		 4w5tA-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		3 / 3 ALA A 642
TRP A 651
VAL A 652
 None
 0.38A 4w9nC-1md7A:
undetectable		 4w9nC-1md7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.40A 4z4gA-1md7A:
0.0		 4z4gA-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 8 SER A 577
GLY A 578
GLY A 470
PHE A 579
 None
 0.91A 5albL-1md7A:
undetectable		 5albL-1md7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.41A 5ki6A-1md7A:
undetectable		 5ki6A-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 5 PRO A 459
GLY A 456
ASN A 457
LYS A 454
 None
 0.93A 5x23A-1md7A:
undetectable		 5x23A-1md7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		4 / 6 PRO A 459
GLY A 456
ASN A 457
LYS A 454
 None
 0.89A 5x24A-1md7A:
undetectable		 5x24A-1md7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		5 / 10 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
 None
 1.16A 6mkeD-1md7A:
undetectable		 6mkeD-1md7A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens) 		3 / 3 ASP A 614
LEU A 607
ARG A 665
 None
 0.74A 7dfrA-1md7A:
undetectable		 7dfrA-1md7A:
18.90