SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mdc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		4 / 7 THR A 117
VAL A 100
THR A 102
VAL A  93
 None
 0.45A 3em0B-1mdcA:
14.0		 3em0B-1mdcA:
27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 PHE A  15
PRO A  37
VAL A 114
ARG A 127
TYR A 129
 None
None
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 0.69A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 PRO A  37
ASP A  77
VAL A 114
ARG A 127
TYR A 129
 None
PLM  A 133 ( 4.4A)
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 1.13A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		4 / 7 PHE A  15
VAL A 114
ARG A 127
TYR A 129
 None
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 0.76A 3p6hA-1mdcA:
19.0		 3p6hA-1mdcA:
31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		4 / 6 VAL A  85
ASN A  88
TYR A   2
TYR A  48
 None
None
ACE  A   0 ( 4.6A)
None
 1.17A 3q5sA-1mdcA:
0.0		 3q5sA-1mdcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 7 ILE A  73
GLY A  74
PHE A  18
PHE A  15
LEU A  19
 PLM  A 133 ( 4.9A)
PLM  A 133 ( 4.1A)
None
None
None
 1.11A 3v7pA-1mdcA:
undetectable		 3v7pA-1mdcA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1mdc INSECT FATTY ACID
BINDING PROTEIN
(Manduca
sexta) 		5 / 12 ARG A 127
GLY A  56
GLY A  55
GLY A  54
VAL A  72
 PLM  A 133 (-3.8A)
None
None
None
None
 1.00A 4htfB-1mdcA:
undetectable		 4htfB-1mdcA:
19.93