SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 12 PHE A  12
ILE A 361
VAL A 335
ALA A 375
ILE A 311
ILE A 292
 None
 1.29A 1epbA-1mewA:
undetectable		 1epbA-1mewA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.88A 1hxwA-1mewA:
undetectable		 1hxwA-1mewA:
12.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 11 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
 0.85A 1jr1A-1mewA:
47.3		 1jr1A-1mewA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 263
ASN A 291
GLY A 314
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
 0.53A 1jr1B-1mewA:
47.4		 1jr1B-1mewA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 261
ASN A 291
GLY A 315
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
None
XMP  A 602 (-3.3A)
 0.66A 1me7A-1mewA:
61.3		 1me7A-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
 0.18A 1me7A-1mewA:
61.3		 1me7A-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
GLY A 314
GLU A 408
GLY A 409
ARG A 414
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
None
 0.75A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
None
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.16A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.8A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.29A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
ILE A 313
GLU A 408
GLY A 409
GLU A 431
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
NAD  A 987 ( 3.5A)
 1.42A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 10 ASP A 261
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 407
 NAD  A 987 (-2.5A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.35A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		8 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
GLU A 408
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
 0.32A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 315
GLU A 408
GLY A 407
 NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
None
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 1.21A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 SER A 263
ASN A 291
GLY A 359
GLU A 408
GLY A 407
 NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.8A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 0.88A 1mehA-1mewA:
60.9		 1mehA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 261
GLU A 408
GLY A 409
ARG A 414
 NAD  A 987 (-2.5A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
None
 0.87A 1meiA-1mewA:
61.9		 1meiA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		7 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
ILE A 313
GLU A 408
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 ( 4.9A)
XMP  A 602 ( 3.1A)
 0.27A 1meiA-1mewA:
61.9		 1meiA-1mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 SER A 263
ASN A 291
GLU A 408
GLY A 407
 NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 ( 4.9A)
XMP  A 602 (-3.3A)
 0.83A 1meiA-1mewA:
61.9		 1meiA-1mewA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 LEU A 369
ALA A 370
LEU A  54
PRO A  53
LEU A  33
 None
 1.16A 1og5A-1mewA:
undetectable		 1og5A-1mewA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 TYR A 405
GLY A 359
GLY A 381
LEU A 380
SER A 317
 XMP  A 602 (-4.7A)
XMP  A 602 ( 3.8A)
XMP  A 602 (-3.6A)
XMP  A 602 (-4.9A)
XMP  A 602 (-3.0A)
 1.24A 1qzzA-1mewA:
undetectable		 1qzzA-1mewA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.88A 1sdtB-1mewA:
undetectable		 1sdtB-1mewA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 11 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
 None
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
None
None
 0.84A 1sduA-1mewA:
undetectable		 1sduA-1mewA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.94A 1sduB-1mewA:
undetectable		 1sduB-1mewA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
 None
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
None
None
 0.86A 1sdvA-1mewA:
undetectable		 1sdvA-1mewA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 ARG A 329
GLY A 374
ASP A 376
ILE A 309
ILE A 353
 None
 1.04A 1sguB-1mewA:
undetectable		 1sguB-1mewA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.82A 2f8gA-1mewA:
undetectable		 2f8gA-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.92A 2ienA-1mewA:
undetectable		 2ienA-1mewA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 GLY A 265
ASP A 264
SER A 262
 None
K  A 900 (-2.4A)
NAD  A 987 (-2.7A)
 0.61A 2qhfA-1mewA:
undetectable		 2qhfA-1mewA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ILE A 378
PHE A  12
GLY A 374
ILE A 466
 None
 0.99A 2qwxA-1mewA:
undetectable
2qwxB-1mewA:
undetectable		 2qwxA-1mewA:
17.71
2qwxB-1mewA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 4 LYS A 403
ALA A 385
PHE A 384
GLY A 381
 None
None
None
XMP  A 602 (-3.6A)
 1.41A 2rddA-1mewA:
0.0		 2rddA-1mewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 6 LEU A 225
ILE A  48
ILE A 277
LEU A 250
 None
 0.87A 2xkwB-1mewA:
undetectable		 2xkwB-1mewA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 VAL A 338
ARG A 329
ASN A 291
GLY A 290
 None
None
XMP  A 602 ( 4.4A)
None
 0.94A 2y05A-1mewA:
undetectable
2y05B-1mewA:
undetectable		 2y05A-1mewA:
24.31
2y05B-1mewA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.81A 2z54A-1mewA:
undetectable		 2z54A-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.86A 2z54B-1mewA:
undetectable		 2z54B-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
 None
 1.33A 3b0wB-1mewA:
undetectable		 3b0wB-1mewA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 ALA A 334
ILE A 313
GLY A 314
GLY A 315
ILE A 311
 None
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
None
None
 0.86A 3cyxB-1mewA:
undetectable		 3cyxB-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.79A 3em3A-1mewA:
undetectable		 3em3A-1mewA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.85A 3ndwA-1mewA:
undetectable		 3ndwA-1mewA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.88A 3ndxA-1mewA:
undetectable		 3ndxA-1mewA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 11 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.90A 3ndxB-1mewA:
undetectable		 3ndxB-1mewA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.96A 3oxvA-1mewA:
undetectable		 3oxvA-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.98A 3pwmB-1mewA:
undetectable		 3pwmB-1mewA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ASN A 446
ALA A 440
ARG A 386
 None
 0.74A 3tj7C-1mewA:
0.0
3tj7D-1mewA:
0.0		 3tj7C-1mewA:
18.53
3tj7D-1mewA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 PHE A 384
THR A  35
LEU A 371
VAL A 454
 None
 0.86A 3ua5A-1mewA:
undetectable		 3ua5A-1mewA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.1A)
 0.44A 4af0A-1mewA:
46.9		 4af0A-1mewA:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 10 ASP A 261
SER A 262
SER A 263
ASN A 291
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.1A)
 0.43A 4af0B-1mewA:
46.9		 4af0B-1mewA:
33.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 261
SER A 262
SER A 263
GLY A 409
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 3.1A)
 0.89A 4fo4A-1mewA:
46.1		 4fo4A-1mewA:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 SER A 262
SER A 263
ASN A 291
GLY A 409
 NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
XMP  A 602 ( 3.1A)
 0.61A 4fo4A-1mewA:
46.1		 4fo4A-1mewA:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 8 SER A 262
SER A 263
ASN A 291
GLY A 314
GLY A 409
 NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.1A)
XMP  A 602 ( 3.1A)
 0.58A 4fo4B-1mewA:
45.5		 4fo4B-1mewA:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 9 ASP A 261
SER A 262
SER A 263
ILE A 313
GLY A 314
 NAD  A 987 (-2.5A)
NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
 1.09A 4fxsA-1mewA:
48.5		 4fxsA-1mewA:
36.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		6 / 9 SER A 262
SER A 263
ASN A 291
ILE A 313
GLY A 314
ASP A 358
 NAD  A 987 (-2.7A)
NAD  A 987 (-3.1A)
XMP  A 602 ( 4.4A)
NAD  A 987 (-4.5A)
NAD  A 987 (-4.1A)
XMP  A 602 (-2.7A)
 0.59A 4fxsA-1mewA:
48.5		 4fxsA-1mewA:
36.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 11 GLY A 288
ASP A 261
GLY A 235
VAL A 247
ILE A 238
 None
NAD  A 987 (-2.5A)
None
None
None
 0.90A 4hlaB-1mewA:
undetectable		 4hlaB-1mewA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ARG A 299
GLU A 296
PHE A 266
 None
 0.95A 4kszA-1mewA:
undetectable		 4kszA-1mewA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ASP A 264
ASP A 358
SER A 263
ALA A 334
 K  A 900 (-2.4A)
XMP  A 602 (-2.7A)
NAD  A 987 (-3.1A)
None
 0.91A 4m48A-1mewA:
undetectable		 4m48A-1mewA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 5 ILE A 378
LEU A  54
ASP A 364
VAL A  31
 None
 0.80A 4nkxB-1mewA:
0.0		 4nkxB-1mewA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 8 ILE A 378
PHE A  12
GLY A 374
ILE A 466
 None
 0.95A 4qogA-1mewA:
undetectable
4qogB-1mewA:
undetectable		 4qogA-1mewA:
17.71
4qogB-1mewA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ARG A 393
TYR A 436
GLU A 404
 None
 0.67A 4zzbE-1mewA:
undetectable		 4zzbE-1mewA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 5 ILE A 397
ARG A 393
TYR A 436
GLU A 404
 None
 1.27A 4zzcE-1mewA:
undetectable		 4zzcE-1mewA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.86A 5a06A-1mewA:
undetectable		 5a06A-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.84A 5a06B-1mewA:
0.8		 5a06B-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.86A 5a06C-1mewA:
undetectable		 5a06C-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 7 ILE A  77
LEU A  71
GLY A  75
GLY A  76
 None
 0.86A 5a06E-1mewA:
undetectable		 5a06E-1mewA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 LEU A  54
ILE A  58
GLY A 235
ILE A  80
GLY A  75
 None
 1.02A 5d4uD-1mewA:
undetectable		 5d4uD-1mewA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		4 / 6 ILE A 378
ALA A 375
LEU A 371
ILE A 466
 None
 0.88A 5mvmB-1mewA:
undetectable
5mvmC-1mewA:
undetectable		 5mvmB-1mewA:
9.87
5mvmC-1mewA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		3 / 3 ARG A 382
PRO A 438
TYR A 363
 None
 0.91A 5tzoB-1mewA:
undetectable		 5tzoB-1mewA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Tritrichomonas
suis) 		5 / 12 PHE A 308
ILE A  77
ILE A  80
TYR A 281
ILE A 277
 None
 1.30A 6mkeB-1mewA:
undetectable
6mkeC-1mewA:
undetectable		 6mkeB-1mewA:
10.02
6mkeC-1mewA:
10.02