SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 8 PHE L 100
PHE L  89
GLN H 289
TYR H 345
 None
 1.47A 2aoxA-1mfaL:
undetectable		 2aoxA-1mfaL:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 6 PHE H 309
TRP L  93
GLY H 350
GLY H 349
 ABE  H 503 ( 4.3A)
ABE  H 503 (-3.6A)
None
None
 0.90A 2qr2A-1mfaH:
0.0
2qr2B-1mfaH:
undetectable		 2qr2A-1mfaH:
20.79
2qr2B-1mfaH:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 5 TRP L  93
GLY H 350
GLY H 349
PHE H 309
 ABE  H 503 (-3.6A)
None
None
ABE  H 503 ( 4.3A)
 0.89A 2qr2A-1mfaL:
undetectable
2qr2B-1mfaL:
undetectable		 2qr2A-1mfaL:
22.32
2qr2B-1mfaL:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 8 PHE H 309
TRP L  93
GLY H 350
GLY H 349
 ABE  H 503 ( 4.3A)
ABE  H 503 (-3.6A)
None
None
 0.84A 2qx4A-1mfaH:
undetectable
2qx4B-1mfaH:
undetectable		 2qx4A-1mfaH:
20.79
2qx4B-1mfaH:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		3 / 3 LEU L  20
LEU L  75
ARG L  63
 None
 0.72A 3hcnB-1mfaL:
undetectable		 3hcnB-1mfaL:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.23A 3jx2A-1mfaL:
0.0
3jx2B-1mfaL:
0.0		 3jx2A-1mfaL:
14.22
3jx2B-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.26A 3jx5A-1mfaL:
0.0
3jx5B-1mfaL:
0.0		 3jx5A-1mfaL:
14.22
3jx5B-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.21A 3jx6A-1mfaL:
0.0
3jx6B-1mfaL:
0.0		 3jx6A-1mfaL:
14.22
3jx6B-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus;
Mus
musculus) 		4 / 4 GLY L  51
TYR H 353
GLY H 355
ASP H 356
 None
 1.23A 3kl3A-1mfaL:
undetectable		 3kl3A-1mfaL:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.22A 3nljA-1mfaL:
undetectable
3nljB-1mfaL:
undetectable		 3nljA-1mfaL:
14.22
3nljB-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.24A 3nlpA-1mfaL:
0.0
3nlpB-1mfaL:
0.0		 3nlpA-1mfaL:
14.22
3nlpB-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 8 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.22A 3nlqA-1mfaL:
undetectable
3nlqB-1mfaL:
undetectable		 3nlqA-1mfaL:
14.22
3nlqB-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 7 VAL L 108
ARG L  63
VAL L  18
GLU L  85
 None
 1.25A 3nlrA-1mfaL:
0.0
3nlrB-1mfaL:
0.0		 3nlrA-1mfaL:
14.22
3nlrB-1mfaL:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 1mfa IGG1-LAMBDA SE155-4
FAB (LIGHT CHAIN)
(Mus
musculus) 		4 / 5 TRP L  98
GLY L  51
ALA L  35
PHE L 100
 ABE  H 503 (-3.9A)
None
None
None
 1.36A 3wqwA-1mfaL:
0.0		 3wqwA-1mfaL:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 5 VAL H 252
TYR H 277
ARG H 348
TYR H 357
 None
 0.41A 4m7kH-1mfaH:
22.6		 4m7kH-1mfaH:
62.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1mfa IGG1-LAMBDA SE155-4
FAB (HEAVY CHAIN)
(Mus
musculus) 		3 / 3 GLY H 292
PRO H 291
ALA H 342
 None
 0.49A 4qn9B-1mfaH:
undetectable		 4qn9B-1mfaH:
15.08