SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_J_TFPJ202_1 (PROTEIN S100-A4)	1mfw	DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN) (Homo sapiens)	5 / 11	LEU A 123 ASP A 121 LEU A 87 PHE A 81 ILE A 76	None	1.21A	3ko0A-1mfwA: undetectable 3ko0B-1mfwA: undetectable 3ko0I-1mfwA: undetectable 3ko0J-1mfwA: undetectable	3ko0A-1mfwA: 21.43 3ko0B-1mfwA: 21.43 3ko0I-1mfwA: 21.43 3ko0J-1mfwA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_A_ACTA5_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	1mfw	DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN) (Homo sapiens)	3 / 3	LYS A 115 SER A 119 GLN A 122	None	1.31A	3si7A-1mfwA: undetectable	3si7A-1mfwA: 17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E0F_A_RBFA301_2 (RIBOFLAVIN SYNTHASE SUBUNIT ALPHA)	1mfw	DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN) (Homo sapiens)	3 / 3	LYS A 116 THR A 107 ILE A 134	SO4 A1002 (-3.5A) None SO4 A1001 (-4.3A)	0.84A	4e0fB-1mfwA: undetectable	4e0fB-1mfwA: 22.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3KO0_J_TFPJ202_1","PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4;PROTEIN S100-A4","1mfw","DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN)","Homo sapiens",5,"LEU A 123;ASP A 121;LEU A  87;PHE A  81;ILE A  76","None","1.21A","3ko0A-1mfwA:undetectable;3ko0B-1mfwA:undetectable;3ko0I-1mfwA:undetectable;3ko0J-1mfwA:undetectable","3ko0A-1mfwA:21.43;3ko0B-1mfwA:21.43;3ko0I-1mfwA:21.43;3ko0J-1mfwA:21.43"],["3SI7_A_ACTA5_0","CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR","1mfw","DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN)","Homo sapiens",3,"LYS A 115;SER A 119;GLN A 122","None","1.31A","3si7A-1mfwA:undetectable","3si7A-1mfwA:17.13"],["4E0F_A_RBFA301_2","RIBOFLAVIN SYNTHASE SUBUNIT ALPHA;RIBOFLAVIN SYNTHASE SUBUNIT ALPHA","1mfw","DOUBLECORTIN-LIKE KINASE (N-TERMINAL DOMAIN)","Homo sapiens",3,"LYS A 116;THR A 107;ILE A 134","SO4 A1002 (-3.5A);None;SO4 A1001 (-4.3A)","0.84A","4e0fB-1mfwA:undetectable","4e0fB-1mfwA:22.51"]]