SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 LEU A 189
PHE A 193
SER A 153
ILE A 146
LEU A 207
 NAI  A 850 (-3.3A)
None
None
None
None
 1.25A 1dreA-1mg5A:
undetectable		 1dreA-1mg5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 TYR A 152
ILE A  18
GLY A 138
ALA A 157
GLY A 183
 ACT  A 900 ( 4.2A)
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.9A)
 0.95A 1kiaA-1mg5A:
7.2		 1kiaA-1mg5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 TYR A 152
ILE A  18
GLY A 138
ALA A 157
GLY A 183
 ACT  A 900 ( 4.2A)
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.9A)
 0.95A 1kiaB-1mg5A:
7.2		 1kiaB-1mg5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 TYR A 152
ILE A  18
GLY A 138
ALA A 157
GLY A 183
 ACT  A 900 ( 4.2A)
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.9A)
 0.96A 1kiaC-1mg5A:
6.9		 1kiaC-1mg5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		3 / 3 ALA A 158
VAL A 160
TRP A 247
 None
 0.90A 1micA-1mg5A:
undetectable
1micB-1mg5A:
undetectable		 1micA-1mg5A:
5.83
1micB-1mg5A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 TYR A 152
ILE A  18
GLY A 138
ALA A 157
GLY A 183
 ACT  A 900 ( 4.2A)
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.9A)
 0.96A 1nbhB-1mg5A:
6.6		 1nbhB-1mg5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 TYR A 152
ILE A  18
GLY A 138
ALA A 157
GLY A 183
 ACT  A 900 ( 4.2A)
NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.9A)
 0.98A 1nbiB-1mg5A:
7.0		 1nbiB-1mg5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 8 GLY A  14
GLY A  16
GLY A  17
LEU A  20
 None
NAI  A 850 (-3.5A)
NAI  A 850 (-3.5A)
None
 0.66A 1qzzA-1mg5A:
5.9		 1qzzA-1mg5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 LEU A 189
PHE A 193
SER A 153
ILE A 146
LEU A 207
 NAI  A 850 (-3.3A)
None
None
None
None
 1.26A 1rh3A-1mg5A:
undetectable		 1rh3A-1mg5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 4 THR A 187
GLY A  14
ASP A  38
ALA A  93
 NAI  A 850 (-2.7A)
None
NAI  A 850 (-2.8A)
NAI  A 850 (-3.5A)
 1.25A 1sg9A-1mg5A:
6.1		 1sg9A-1mg5A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 ILE A 226
ALA A 225
ASN A 136
PHE A 222
VAL A   9
 None
 1.11A 1xdkA-1mg5A:
undetectable		 1xdkA-1mg5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 11 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
 NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
 1.02A 2y7kA-1mg5A:
1.1		 2y7kA-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
 NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
 1.12A 2y7kC-1mg5A:
undetectable		 2y7kC-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 ILE A  18
GLY A  19
PHE A  11
GLY A  92
PRO A 182
 NAI  A 850 (-3.9A)
None
None
NAI  A 850 (-4.6A)
NAI  A 850 (-3.8A)
 1.13A 2y7kD-1mg5A:
0.4		 2y7kD-1mg5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 10 ILE A 137
GLY A  92
GLY A  14
THR A  22
PRO A 182
 NAI  A 850 (-4.1A)
NAI  A 850 (-4.6A)
None
None
NAI  A 850 (-3.8A)
 1.26A 2y7wB-1mg5A:
0.0		 2y7wB-1mg5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 5 VAL A 159
VAL A 160
THR A 116
THR A 155
 None
 1.28A 3bjwD-1mg5A:
0.0		 3bjwD-1mg5A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 ILE A  36
PHE A  11
ALA A  45
LEU A  49
LEU A 216
 None
 1.03A 3ozuA-1mg5A:
5.0		 3ozuA-1mg5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 9 THR A 116
THR A 115
ASN A 114
TYR A  63
ASP A  64
 None
None
None
None
NAI  A 850 (-3.4A)
 1.45A 3sfuA-1mg5A:
undetectable		 3sfuA-1mg5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		3 / 3 PRO A 211
THR A 212
LEU A 208
 None
 0.62A 3ttrA-1mg5A:
undetectable		 3ttrA-1mg5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 5 SER A 139
ILE A  18
TYR A 152
GLY A 183
 ACT  A 900 ( 2.9A)
NAI  A 850 (-3.9A)
ACT  A 900 ( 4.2A)
NAI  A 850 (-4.9A)
 1.06A 3uboB-1mg5A:
4.8		 3uboB-1mg5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 8 ILE A  46
ILE A  36
SER A 215
GLY A  19
 None
 0.85A 4ac9C-1mg5A:
6.6		 4ac9C-1mg5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 8 LEU A  20
LEU A  15
GLY A  14
VAL A  58
 None
 0.83A 4c9nA-1mg5A:
0.0		 4c9nA-1mg5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		3 / 3 HIS A 191
VAL A 149
LEU A  96
 None
 0.64A 4m2vA-1mg5A:
undetectable		 4m2vA-1mg5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 ALA A  13
GLY A  14
SER A  23
GLY A  94
ASN A  91
 NAI  A 850 (-3.2A)
None
None
NAI  A 850 (-3.5A)
None
 1.04A 4obwA-1mg5A:
6.2		 4obwA-1mg5A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		4 / 4 GLY A 142
VAL A 160
PHE A 222
ILE A 137
 None
None
None
NAI  A 850 (-4.1A)
 1.08A 4xv2B-1mg5A:
0.6		 4xv2B-1mg5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 VAL A  65
ASP A  64
LEU A 189
ALA A  13
THR A 188
 NAI  A 850 (-3.5A)
NAI  A 850 (-3.4A)
NAI  A 850 (-3.3A)
NAI  A 850 (-3.2A)
NAI  A 850 ( 4.9A)
 1.35A 5hnzB-1mg5A:
8.7		 5hnzB-1mg5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 GLY A  92
TYR A  63
ALA A  93
ILE A  10
LEU A  89
 NAI  A 850 (-4.6A)
None
NAI  A 850 (-3.5A)
None
None
 1.19A 6b3aA-1mg5A:
5.8		 6b3aA-1mg5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1mg5 ALCOHOL
DEHYDROGENASE
(Drosophila
melanogaster) 		5 / 12 GLY A  92
TYR A  63
ALA A  93
ILE A  10
LEU A  89
 NAI  A 850 (-4.6A)
None
NAI  A 850 (-3.5A)
None
None
 1.15A 6b3bA-1mg5A:
6.0		 6b3bA-1mg5A:
18.38