SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		4 / 5 SER A  61
PHE A   7
VAL A  18
PHE A  20
 None
 1.05A 1oipA-1mgtA:
undetectable		 1oipA-1mgtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 11 VAL A 126
GLY A 127
ASP A 114
ILE A 110
VAL A 144
 None
 1.19A 1phgA-1mgtA:
undetectable		 1phgA-1mgtA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 10 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 1.10A 1pxxA-1mgtA:
undetectable		 1pxxA-1mgtA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 1.09A 1pxxC-1mgtA:
0.0		 1pxxC-1mgtA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		4 / 8 LEU A  56
ILE A  54
LEU A  43
HIS A  41
 None
 0.94A 2azxA-1mgtA:
undetectable		 2azxA-1mgtA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 TYR A 112
LEU A 115
VAL A  96
MET A 130
LEU A 164
 SO4  A 301 (-4.4A)
None
None
None
None
 1.33A 2prgB-1mgtA:
undetectable		 2prgB-1mgtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		3 / 3 ARG A  33
ASP A  57
GLN A  25
 None
 0.90A 3lcvB-1mgtA:
undetectable		 3lcvB-1mgtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		4 / 7 LEU A 163
SER A 155
THR A  35
VAL A  14
 None
 1.06A 4wnvD-1mgtA:
undetectable		 4wnvD-1mgtA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 0.99A 5ikqA-1mgtA:
undetectable		 5ikqA-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 1.01A 5ikqB-1mgtA:
undetectable		 5ikqB-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 VAL A 138
LEU A  43
VAL A  18
GLY A  26
LEU A  84
 None
 1.03A 5iktA-1mgtA:
undetectable		 5iktA-1mgtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		5 / 12 TYR A 153
GLY A 156
PHE A 162
ILE A  27
ALA A  28
 None
 0.87A 5n0xA-1mgtA:
undetectable		 5n0xA-1mgtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)
(Thermococcus
kodakarensis) 		6 / 12 LEU A  84
TYR A 112
LEU A 115
VAL A  96
MET A 130
LEU A 164
 None
SO4  A 301 (-4.4A)
None
None
None
None
 1.23A 5ycnA-1mgtA:
undetectable		 5ycnA-1mgtA:
20.89