SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PJ7_A_FFOA2887_1 (N,N-DIMETHYLGLYCINE OXIDASE)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	ASP A 198 THR A 200 GLU A 229	None	0.81A	1pj7A-1mhcA: undetectable	1pj7A-1mhcA: 16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_C_DVAC6_0 (GRAMICIDIN D)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	ALA A 187 VAL A 189 TRP A 217	None	0.86A	1w5uC-1mhcA: undetectable 1w5uD-1mhcA: undetectable	1w5uC-1mhcA: 4.78 1w5uD-1mhcA: 4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JN3_A_JN3A130_1 (FATTY ACID-BINDING PROTEIN, LIVER)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	5 / 12	TYR A 114 LEU A 95 ALA A 116 ILE A 124 THR A 143	None	1.04A	2jn3A-1mhcA: undetectable	2jn3A-1mhcA: 17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YZQ_A_SAMA6075_0 (PUTATIVE UNCHARACTERIZED PROTEIN PH1780)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	5 / 12	ILE A 213 ASP A 212 THR A 214 VAL A 261 PRO A 185	None	1.21A	2yzqA-1mhcA: undetectable	2yzqA-1mhcA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_B_H3PB552_1 (GLUTAMATE DEHYDROGENASE)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	TYR A 7 TYR A 22 ILE A 70	None	0.79A	3eteA-1mhcA: undetectable 3eteB-1mhcA: undetectable	3eteA-1mhcA: 21.29 3eteB-1mhcA: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_C_DVAC6_0 (GRAMICIDIN D)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	ALA A 187 VAL A 189 TRP A 217	None	0.82A	3l8lC-1mhcA: undetectable 3l8lD-1mhcA: undetectable	3l8lC-1mhcA: 4.78 3l8lD-1mhcA: 4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA615_1 (PHIAB6 TAILSPIKE)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	TYR A 59 TYR A 7 GLN A 34	None	1.03A	5jsdA-1mhcA: 0.0 5jsdB-1mhcA: 0.0	5jsdA-1mhcA: 17.85 5jsdB-1mhcA: 17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB606_1 (PHIAB6 TAILSPIKE)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	3 / 3	TYR A 59 TYR A 7 GLN A 34	None	1.04A	5jsdB-1mhcA: 0.0 5jsdC-1mhcA: 0.0	5jsdB-1mhcA: 17.85 5jsdC-1mhcA: 17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_A_ASCA1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	4 / 6	VAL A 67 TYR A 22 GLN A 34 HIS A 9	None	1.05A	5kkzA-1mhcA: undetectable 5kkzG-1mhcA: 0.5	5kkzA-1mhcA: 19.03 5kkzG-1mhcA: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_E_ASCE1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	4 / 7	HIS A 9 VAL A 67 TYR A 22 GLN A 34	None	1.08A	5kkzC-1mhcA: 0.0 5kkzE-1mhcA: undetectable	5kkzC-1mhcA: 20.69 5kkzE-1mhcA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_K_ASCK1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	4 / 7	VAL A 67 TYR A 22 GLN A 34 HIS A 9	None	1.07A	5kkzK-1mhcA: undetectable 5kkzQ-1mhcA: 0.5	5kkzK-1mhcA: 19.03 5kkzQ-1mhcA: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKZ_O_ASCO1004_0 (CYTOCHROME B UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT)	1mhc	MHC CLASS I ANTIGEN H2-M3 (Mus musculus)	4 / 7	HIS A 9 VAL A 67 TYR A 22 GLN A 34	None	1.05A	5kkzM-1mhcA: 0.0 5kkzO-1mhcA: undetectable	5kkzM-1mhcA: 20.69 5kkzO-1mhcA: 19.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PJ7_A_FFOA2887_1","N,N-DIMETHYLGLYCINE OXIDASE","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"ASP A 198;THR A 200;GLU A 229","None","0.81A","1pj7A-1mhcA:undetectable","1pj7A-1mhcA:16.16"],["1W5U_C_DVAC6_0","GRAMICIDIN D","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"ALA A 187;VAL A 189;TRP A 217","None","0.86A","1w5uC-1mhcA:undetectable;1w5uD-1mhcA:undetectable","1w5uC-1mhcA:4.78;1w5uD-1mhcA:4.78"],["2JN3_A_JN3A130_1","FATTY ACID-BINDING PROTEIN, LIVER","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",5,"TYR A 114;LEU A  95;ALA A 116;ILE A 124;THR A 143","None","1.04A","2jn3A-1mhcA:undetectable","2jn3A-1mhcA:17.78"],["2YZQ_A_SAMA6075_0","PUTATIVE UNCHARACTERIZED PROTEIN PH1780","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",5,"ILE A 213;ASP A 212;THR A 214;VAL A 261;PRO A 185","None","1.21A","2yzqA-1mhcA:undetectable","2yzqA-1mhcA:22.46"],["3ETE_B_H3PB552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"TYR A   7;TYR A  22;ILE A  70","None","0.79A","3eteA-1mhcA:undetectable;3eteB-1mhcA:undetectable","3eteA-1mhcA:21.29;3eteB-1mhcA:21.29"],["3L8L_C_DVAC6_0","GRAMICIDIN D","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"ALA A 187;VAL A 189;TRP A 217","None","0.82A","3l8lC-1mhcA:undetectable;3l8lD-1mhcA:undetectable","3l8lC-1mhcA:4.78;3l8lD-1mhcA:4.78"],["5JSD_A_1GNA615_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"TYR A  59;TYR A   7;GLN A  34","None","1.03A","5jsdA-1mhcA:0.0;5jsdB-1mhcA:0.0","5jsdA-1mhcA:17.85;5jsdB-1mhcA:17.85"],["5JSD_B_1GNB606_1","PHIAB6 TAILSPIKE;PHIAB6 TAILSPIKE","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",3,"TYR A  59;TYR A   7;GLN A  34","None","1.04A","5jsdB-1mhcA:0.0;5jsdC-1mhcA:0.0","5jsdB-1mhcA:17.85;5jsdC-1mhcA:17.85"],["5KKZ_A_ASCA1004_0","CYTOCHROME B;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",4,"VAL A  67;TYR A  22;GLN A  34;HIS A   9","None","1.05A","5kkzA-1mhcA:undetectable;5kkzG-1mhcA:0.5","5kkzA-1mhcA:19.03;5kkzG-1mhcA:20.69"],["5KKZ_E_ASCE1004_0","CYTOCHROME B;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",4,"HIS A   9;VAL A  67;TYR A  22;GLN A  34","None","1.08A","5kkzC-1mhcA:0.0;5kkzE-1mhcA:undetectable","5kkzC-1mhcA:20.69;5kkzE-1mhcA:19.03"],["5KKZ_K_ASCK1004_0","CYTOCHROME B;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",4,"VAL A  67;TYR A  22;GLN A  34;HIS A   9","None","1.07A","5kkzK-1mhcA:undetectable;5kkzQ-1mhcA:0.5","5kkzK-1mhcA:19.03;5kkzQ-1mhcA:20.69"],["5KKZ_O_ASCO1004_0","CYTOCHROME B;UBIQUINOL-CYTOCHROME C REDUCTASE IRON-SULFUR SUBUNIT","1mhc","MHC CLASS I ANTIGEN H2-M3","Mus musculus",4,"HIS A   9;VAL A  67;TYR A  22;GLN A  34","None","1.05A","5kkzM-1mhcA:0.0;5kkzO-1mhcA:undetectable","5kkzM-1mhcA:20.69;5kkzO-1mhcA:19.03"]]