SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		4 / 8 TYR A 152
ARG A 130
GLU A 133
VAL A 113
 None
 1.18A 2fl5E-1mhqA:
undetectable
2fl5F-1mhqA:
undetectable		 2fl5E-1mhqA:
19.91
2fl5F-1mhqA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		5 / 8 LEU A  26
LEU A  30
CYH A  93
VAL A  85
ILE A  46
 None
 1.33A 2uxpA-1mhqA:
2.0		 2uxpA-1mhqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		4 / 5 SER A 121
GLY A 129
GLU A  87
GLU A 133
 None
 1.49A 3raeB-1mhqA:
0.0
3raeD-1mhqA:
undetectable		 3raeB-1mhqA:
15.80
3raeD-1mhqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		3 / 3 VAL A  53
HIS A  98
VAL A 101
 None
 0.60A 5jmnC-1mhqA:
2.4		 5jmnC-1mhqA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		5 / 12 VAL A 131
VAL A  85
PHE A 106
LEU A  66
VAL A 101
 None
 1.18A 5tudA-1mhqA:
undetectable		 5tudA-1mhqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens) 		4 / 6 PHE A  97
PRO A  60
GLY A  59
ASN A  58
 None
 0.96A 5x24A-1mhqA:
0.0		 5x24A-1mhqA:
14.59