SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mhy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		3 / 3 GLU B  92
THR B  91
LEU B 306
 None
 0.60A 1v8bC-1mhyB:
undetectable		 1v8bC-1mhyB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 7 LEU B 320
ASN B 321
GLU B 325
LEU B 328
 None
 0.68A 2w8yA-1mhyB:
0.0		 2w8yA-1mhyB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 10 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
 None
 1.16A 2wuzA-1mhyB:
0.4		 2wuzA-1mhyB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 7 SER B 168
ILE B 247
ASP B 172
TRP B 244
 None
 1.18A 2x45B-1mhyB:
undetectable		 2x45B-1mhyB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 7 SER B 168
ILE B 247
ASP B 172
TRP B 244
 None
 1.19A 2x45C-1mhyB:
undetectable		 2x45C-1mhyB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 8 GLU B 266
THR B 273
VAL B 274
LEU B 271
 None
 1.02A 3ax7A-1mhyB:
0.0		 3ax7A-1mhyB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 7 SER B 168
ILE B 247
ASP B 172
TRP B 244
 None
 1.19A 3bu1A-1mhyB:
undetectable		 3bu1A-1mhyB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 5 ASN B 245
ALA B 185
LEU B 162
GLY B 251
 None
 0.97A 3dl9A-1mhyB:
1.7		 3dl9A-1mhyB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 12 VAL B 254
GLY B 251
ALA B 230
GLY B 229
ILE B 237
 None
 0.91A 3ku1A-1mhyB:
undetectable		 3ku1A-1mhyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 12 VAL B 254
GLY B 251
ALA B 230
GLY B 229
ILE B 237
 None
 0.92A 3ku1C-1mhyB:
undetectable		 3ku1C-1mhyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 8 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
 None
 1.16A 3l4dA-1mhyB:
undetectable		 3l4dA-1mhyB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_B_TPFB490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 9 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
 None
 1.14A 3l4dB-1mhyB:
0.7		 3l4dB-1mhyB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 9 PHE B 338
TYR B 227
ALA B 263
THR B 280
LEU B 148
 None
 1.20A 3l4dC-1mhyB:
undetectable		 3l4dC-1mhyB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 11 THR B 258
GLN B 261
ALA B 250
GLY B 251
ALA B 253
 None
 1.13A 3mg0H-1mhyB:
0.0
3mg0I-1mhyB:
0.0		 3mg0H-1mhyB:
20.16
3mg0I-1mhyB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 5 VAL G 139
LEU G 140
ILE G 111
ALA G 102
 None
 0.99A 3n8yB-1mhyG:
undetectable		 3n8yB-1mhyG:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 7 GLU B 266
THR B 273
VAL B 274
LEU B 271
 None
 1.02A 3uniA-1mhyB:
0.0		 3uniA-1mhyB:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 5 VAL B 364
LEU B 335
VAL B 389
PHE B 365
 None
 0.99A 4lb0B-1mhyB:
undetectable		 4lb0B-1mhyB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		3 / 3 ASP B 188
LEU B 187
PHE B 184
 None
 0.44A 4pthA-1mhyB:
undetectable		 4pthA-1mhyB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 8 THR B  91
LEU B 320
VAL G  75
LEU G  78
 None
 0.93A 4r38B-1mhyB:
undetectable		 4r38B-1mhyB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 12 SER B 175
ILE B  66
PRO B  63
GLN G  55
SER B  90
 None
 1.35A 4uroA-1mhyB:
undetectable		 4uroA-1mhyB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		3 / 3 ASP B  97
LEU B  70
GLY B  69
 None
 0.57A 4xmfA-1mhyB:
undetectable		 4xmfA-1mhyB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		3 / 3 ASN B 245
ASP B 309
GLY B 313
 None
 0.64A 5fctB-1mhyB:
undetectable		 5fctB-1mhyB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		4 / 6 VAL B 380
VAL B 254
ILE B 298
PHE B 302
 None
 1.00A 5jw1B-1mhyB:
undetectable		 5jw1B-1mhyB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 12 THR B 258
GLN B 261
ALA B 250
GLY B 251
ALA B 253
 None
 1.07A 5l5zH-1mhyB:
0.0
5l5zI-1mhyB:
0.0		 5l5zH-1mhyB:
20.81
5l5zI-1mhyB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		5 / 12 THR B 258
GLN B 261
ALA B 250
GLY B 251
ALA B 253
 None
 1.09A 5l5zV-1mhyB:
0.0
5l5zW-1mhyB:
0.0		 5l5zV-1mhyB:
20.81
5l5zW-1mhyB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		3 / 3 GLY G 137
LEU G 140
HIS B  80
 None
 0.70A 5u63A-1mhyG:
undetectable		 5u63A-1mhyG:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium) 		3 / 3 PHE B 378
ASP B 374
LYS B 369
 None
 0.79A 6awtD-1mhyB:
0.0		 6awtD-1mhyB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		4 / 6 PHE B 319
ILE G  79
ASN G 127
ASP B 243
 None
 1.50A 6dhbA-1mhyB:
undetectable		 6dhbA-1mhyB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1mhy METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE
(Methylosinus
trichosporium;
Methylosinus
trichosporium) 		3 / 3 PHE G 129
ARG B  83
ALA G 135
 None
 0.93A 6ecfB-1mhyG:
undetectable		 6ecfB-1mhyG:
21.38