SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		4 / 8 ASP D 143
ASP D 122
TYR D 126
THR E 141
 None
 1.22A 1ceaA-1mi5D:
0.0
1ceaB-1mi5D:
0.0		 1ceaA-1mi5D:
15.92
1ceaB-1mi5D:
15.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1mi5 TCR ALPHA CHAIN
(Homo
sapiens) 		5 / 8 TYR D  88
LEU D  82
LEU D 112
SER D  12
GLU D  15
 None
 1.21A 1i7zA-1mi5D:
13.8		 1i7zA-1mi5D:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		3 / 3 ARG D 129
ILE E 138
TRP E 204
 None
 1.04A 1m8eB-1mi5D:
undetectable		 1m8eB-1mi5D:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY E  40
GLN E  37
GLU E  44
ILE D 111
GLN D 108
 None
 1.20A 2azxA-1mi5E:
undetectable		 2azxA-1mi5E:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		5 / 12 ALA E 240
VAL E 199
HIS E 210
PHE E 211
SER D 131
 None
 1.36A 2gl0A-1mi5E:
0.0
2gl0C-1mi5E:
0.2		 2gl0A-1mi5E:
23.39
2gl0C-1mi5E:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		5 / 12 HIS E 210
PHE E 211
SER D 131
ALA E 240
VAL E 199
 None
 1.37A 2gl0D-1mi5E:
0.2
2gl0E-1mi5E:
0.3		 2gl0D-1mi5E:
23.39
2gl0E-1mi5E:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR E  35
TYR D  35
PRO D  43
TYR D  89
 None
 1.14A 2ombC-1mi5E:
19.9
2ombD-1mi5E:
15.0		 2ombC-1mi5E:
33.85
2ombD-1mi5E:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1mi5 TCR ALPHA CHAIN
(Homo
sapiens) 		5 / 11 VAL D 150
ILE D 118
LYS D 174
SER D 175
THR D 164
 None
 1.35A 3bjwE-1mi5D:
undetectable		 3bjwE-1mi5D:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		3 / 3 ARG D 129
ILE E 138
TRP E 204
 None
 1.00A 3e68A-1mi5D:
undetectable		 3e68A-1mi5D:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		3 / 3 ARG D 129
ILE E 138
TRP E 204
 None
 1.07A 3e6tB-1mi5D:
undetectable		 3e6tB-1mi5D:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		4 / 7 GLY D 107
PHE D 106
PHE E  33
PHE E 108
 None
 1.13A 3ko0D-1mi5D:
undetectable
3ko0E-1mi5D:
undetectable		 3ko0D-1mi5D:
20.62
3ko0E-1mi5D:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		4 / 5 GLN D 127
GLU E 137
THR E 141
HIS E 140
 None
 1.48A 3n58A-1mi5D:
undetectable		 3n58A-1mi5D:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1mi5 TCR ALPHA CHAIN
(Homo
sapiens) 		4 / 6 PHE D 187
ASN D 191
PHE D 193
THR D 202
 None
 1.16A 3t3sB-1mi5D:
undetectable		 3t3sB-1mi5D:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLN E 106
PHE E 108
TYR D  35
 None
 1.00A 3ucjA-1mi5E:
undetectable		 3ucjA-1mi5E:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN
(Homo
sapiens) 		3 / 3 GLU E 132
TRP E 204
LYS D 132
 None
 1.49A 4k7aA-1mi5E:
undetectable		 4k7aA-1mi5E:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1mi5 TCR ALPHA CHAIN
(Homo
sapiens) 		3 / 3 MET D 168
ASP D 143
PHE D 144
 None
 1.07A 4xeyA-1mi5D:
0.5		 4xeyA-1mi5D:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1mi5 TCR ALPHA CHAIN
(Homo
sapiens) 		4 / 8 ARG D  36
TYR D  35
GLY D 107
PHE D 106
 None
 0.90A 5nooD-1mi5D:
undetectable		 5nooD-1mi5D:
22.22