SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mjf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLU A 104
ASP A 141
GLY A 142
LEU A 169
 None
 0.76A 1jg2A-1mjfA:
8.2		 1jg2A-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
GLU A 104
ASP A 141
GLY A 142
 None
 0.56A 1jg2A-1mjfA:
8.2		 1jg2A-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 11 GLY A  82
GLY A  84
GLU A 104
ASP A 141
GLY A 142
LEU A 169
 None
 0.84A 1jg3A-1mjfA:
7.8		 1jg3A-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  83
GLU A 104
ASP A 141
GLY A 142
LEU A 169
 None
 0.87A 1jg3A-1mjfA:
7.8		 1jg3A-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 11 GLY A  82
GLY A  84
GLU A 104
ASP A 141
GLY A 142
LEU A 169
 None
 0.84A 1jg3B-1mjfA:
7.9		 1jg3B-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  83
GLU A 104
ASP A 141
GLY A 142
LEU A 169
 None
 0.90A 1jg3B-1mjfA:
7.9		 1jg3B-1mjfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 TYR A   8
HIS A  61
TYR A  60
GLY A  56
 None
 1.17A 1mxgA-1mjfA:
undetectable		 1mxgA-1mjfA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  84
GLY A  86
GLY A  87
ASP A 106
VAL A 109
 None
 0.87A 1n2xB-1mjfA:
13.3		 1n2xB-1mjfA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 238
VAL A 236
ILE A 187
ALA A 157
ILE A 156
 None
 0.92A 1pbkA-1mjfA:
undetectable		 1pbkA-1mjfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
ILE A 105
ASP A 106
ASP A 141
 None
 0.57A 1qaoA-1mjfA:
7.0		 1qaoA-1mjfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  83
GLY A  84
GLU A 104
ASP A 141
 None
 0.68A 1qzzA-1mjfA:
12.3		 1qzzA-1mjfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 GLY A  86
GLY A  87
ILE A 105
ASP A 106
ASP A 141
GLY A 142
 None
 0.45A 1sqfA-1mjfA:
5.9		 1sqfA-1mjfA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  83
GLY A  84
GLU A 104
ASP A 141
 None
 0.69A 1xdsA-1mjfA:
11.2		 1xdsA-1mjfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  83
GLY A  84
GLU A 104
ASP A 141
 None
 0.68A 1xdsB-1mjfA:
11.5		 1xdsB-1mjfA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 8 GLY A  83
GLY A  84
LEU A 124
ILE A 119
HIS A  61
 None
 1.00A 1yajC-1mjfA:
undetectable		 1yajC-1mjfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 GLY A  82
GLU A 104
ASP A 158
 None
 0.68A 2b25B-1mjfA:
10.5		 2b25B-1mjfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  84
GLY A  87
ASP A 106
ASP A 141
LEU A 169
 None
 1.02A 2hmyB-1mjfA:
6.9		 2hmyB-1mjfA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
ILE A 105
ASP A 106
LEU A 169
 None
 0.79A 2nxeB-1mjfA:
12.9		 2nxeB-1mjfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 GLY A  84
ASP A  85
SER A 113
 None
 0.74A 2qhfA-1mjfA:
undetectable		 2qhfA-1mjfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 VAL A  34
TYR A  23
VAL A 112
ASP A 115
 None
 1.09A 2x45C-1mjfA:
0.0		 2x45C-1mjfA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  84
ILE A 117
LEU A 123
VAL A  65
 None
 0.95A 2yqzB-1mjfA:
11.5		 2yqzB-1mjfA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 PRO A  67
LEU A  70
ARG A 247
 None
 0.83A 3aqiA-1mjfA:
3.1		 3aqiA-1mjfA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		8 / 12 GLN A  51
TYR A  60
HIS A  61
ASP A  85
ASP A 158
ASP A 161
GLN A 191
TYR A 226
 None
 0.48A 3b7pA-1mjfA:
36.6		 3b7pA-1mjfA:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		8 / 12 GLN A  51
TYR A  60
HIS A  61
ASP A  85
ASP A 158
ASP A 161
GLN A 191
TYR A 226
 None
 0.47A 3b7pB-1mjfA:
36.6		 3b7pB-1mjfA:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		8 / 12 GLN A  51
TYR A  60
HIS A  61
ASP A  85
ASP A 158
ASP A 161
SER A 194
TYR A 226
 None
 0.58A 3b7pC-1mjfA:
36.8		 3b7pC-1mjfA:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 TYR A  60
HIS A  61
ASP A  85
ASP A 158
SER A 220
 None
 1.49A 3b7pC-1mjfA:
36.8		 3b7pC-1mjfA:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 SER A 228
PRO A 229
PHE A 221
PRO A 222
 None
 1.41A 3bjwC-1mjfA:
undetectable		 3bjwC-1mjfA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 GLN A  30
TYR A  60
GLY A  83
ASP A 106
VAL A 109
GLN A 191
 None
 1.21A 3bwcA-1mjfA:
33.1		 3bwcA-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		11 / 12 GLN A  30
TYR A  60
HIS A  61
ILE A  81
GLY A  82
ILE A 105
ASP A 106
VAL A 109
ASP A 141
GLY A 142
GLN A 191
 None
 0.56A 3bwcA-1mjfA:
33.1		 3bwcA-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLN A  30
TYR A 226
ILE A 105
ASP A 106
VAL A 109
 None
 1.05A 3bwcA-1mjfA:
33.1		 3bwcA-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 LEU A  46
TYR A  60
GLY A  83
ASP A 106
VAL A 109
ASP A 158
 None
 1.12A 3bwcB-1mjfA:
32.7		 3bwcB-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 LEU A  46
TYR A  60
GLY A  83
ASP A 106
VAL A 109
GLN A 191
 None
 1.24A 3bwcB-1mjfA:
32.7		 3bwcB-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		11 / 12 LEU A  46
TYR A  60
HIS A  61
ILE A  81
GLY A  82
ASP A  85
ILE A 105
ASP A 106
VAL A 109
GLY A 142
ASP A 158
 None
 0.35A 3bwcB-1mjfA:
32.7		 3bwcB-1mjfA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		11 / 12 LEU A  46
TYR A  60
HIS A  61
ILE A  81
GLY A  82
ASP A  85
ILE A 105
ASP A 106
VAL A 109
GLY A 142
GLN A 191
 None
 0.53A 3bwcB-1mjfA:
32.7		 3bwcB-1mjfA:
34.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		7 / 11 VAL A  50
TYR A  60
ASP A  85
ASP A 158
GLN A 191
TYR A 226
TRP A 230
 None
 0.57A 3c6mA-1mjfA:
26.1		 3c6mA-1mjfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 9 TYR A  60
ASP A  85
ASP A 158
GLN A 191
TYR A 226
TRP A 230
 None
 0.50A 3c6mB-1mjfA:
26.0		 3c6mB-1mjfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		7 / 10 VAL A  50
TYR A  60
ASP A  85
ASP A 158
GLN A 191
TYR A 226
TRP A 230
 None
 0.55A 3c6mC-1mjfA:
25.9		 3c6mC-1mjfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 10 TYR A  60
ASP A  85
ASP A 158
GLN A 191
TYR A 226
TRP A 230
 None
 0.48A 3c6mD-1mjfA:
26.0		 3c6mD-1mjfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
ILE A 105
ASP A 106
LEU A 169
 None
 0.74A 3cjtG-1mjfA:
12.7		 3cjtG-1mjfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
ILE A 105
ASP A 106
LEU A 169
 None
 0.73A 3cjtO-1mjfA:
12.9		 3cjtO-1mjfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLY A  84
GLU A 104
ASP A 106
ASP A 141
 None
 0.58A 3fuuA-1mjfA:
11.3		 3fuuA-1mjfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  82
GLU A 104
ILE A 105
ASP A 106
ASP A 141
 None
 0.31A 3grvA-1mjfA:
12.0		 3grvA-1mjfA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  82
GLU A 104
ILE A 105
ASP A 106
ASP A 141
 None
 0.39A 3gryA-1mjfA:
11.8		 3gryA-1mjfA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
ASP A 106
ASP A 158
LEU A 169
 None
 0.85A 3m6vA-1mjfA:
10.3		 3m6vA-1mjfA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
ASP A 106
ASP A 158
LEU A 169
 None
 0.84A 3m6vB-1mjfA:
10.2		 3m6vB-1mjfA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 4 GLY A  82
GLU A 104
ASP A 141
ASP A 158
 None
 0.83A 3mb5A-1mjfA:
14.1		 3mb5A-1mjfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 188
GLY A 186
ALA A  68
ASP A 153
VAL A 154
 None
 1.25A 3nvkF-1mjfA:
0.0
3nvkJ-1mjfA:
12.4		 3nvkF-1mjfA:
25.26
3nvkJ-1mjfA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 GLY A  84
GLY A  86
THR A  88
 None
 0.38A 3si7B-1mjfA:
undetectable		 3si7B-1mjfA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  84
GLU A 104
ASP A 141
ASP A 158
 None
 0.80A 3vywC-1mjfA:
15.3		 3vywC-1mjfA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 189
TYR A 175
ILE A 187
ILE A 155
PHE A 174
 None
 1.28A 4afgA-1mjfA:
0.0
4afgB-1mjfA:
0.0		 4afgA-1mjfA:
20.33
4afgB-1mjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
ILE A 155
PHE A 174
VAL A 189
TYR A 175
 None
 1.13A 4afgA-1mjfA:
0.0
4afgE-1mjfA:
0.0		 4afgA-1mjfA:
20.33
4afgE-1mjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 189
TYR A 175
ILE A 187
ILE A 155
 None
 0.89A 4afgD-1mjfA:
0.0
4afgE-1mjfA:
0.0		 4afgD-1mjfA:
20.33
4afgE-1mjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 189
TYR A 175
ILE A 187
ILE A 155
PHE A 174
 None
 1.24A 4afgC-1mjfA:
0.0
4afgD-1mjfA:
0.0		 4afgC-1mjfA:
20.33
4afgD-1mjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 189
TYR A 175
ILE A 187
ILE A 155
PHE A 174
 None
 1.21A 4afgB-1mjfA:
0.0
4afgC-1mjfA:
0.0		 4afgB-1mjfA:
20.33
4afgC-1mjfA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 6 HIS A  61
GLU A 104
ASP A 141
ASP A 158
 None
 1.36A 4blvA-1mjfA:
11.6		 4blvA-1mjfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 TYR A 226
THR A 160
ILE A 117
VAL A  34
ILE A  32
 None
 1.17A 4eb6B-1mjfA:
2.0
4eb6C-1mjfA:
undetectable		 4eb6B-1mjfA:
21.43
4eb6C-1mjfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
 None
 1.02A 4fp9A-1mjfA:
10.4		 4fp9A-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
 None
 1.02A 4fp9C-1mjfA:
10.4		 4fp9C-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
ASP A 141
GLY A 142
LEU A 169
 None
 0.67A 4fp9D-1mjfA:
10.7		 4fp9D-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
GLY A 142
ASP A 158
LEU A 169
 None
 1.02A 4fp9F-1mjfA:
10.4		 4fp9F-1mjfA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  86
GLY A  87
ASP A 141
GLY A 142
LEU A 169
 None
 0.61A 4fzvA-1mjfA:
10.3		 4fzvA-1mjfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 104
ASP A 106
ASP A 141
 None
 0.20A 4gc9A-1mjfA:
9.8		 4gc9A-1mjfA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 GLU A   6
VAL A  14
VAL A  53
PHE A  16
 None
 1.01A 4lb0B-1mjfA:
undetectable		 4lb0B-1mjfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 151
ILE A 146
ASN A 149
TYR A 188
ASP A 153
 None
 1.27A 4rtpA-1mjfA:
9.9		 4rtpA-1mjfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 ARG A  58
ARG A  42
GLY A  41
GLU A  36
 None
 1.18A 4z3oA-1mjfA:
undetectable
4z3oB-1mjfA:
undetectable		 4z3oA-1mjfA:
17.17
4z3oB-1mjfA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 GLY A  82
GLY A  84
ASP A 141
ASP A 158
 None
 0.82A 5ergB-1mjfA:
10.1		 5ergB-1mjfA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  87
ASP A 141
GLY A 142
ASP A 158
LEU A 169
 None
 1.07A 5wwsA-1mjfA:
9.4		 5wwsA-1mjfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  82
GLU A 104
ASP A 141
SER A 159
LEU A 169
 None
 0.98A 5x6yC-1mjfA:
6.9		 5x6yC-1mjfA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		7 / 12 GLN A  30
GLY A  82
ILE A 105
ASP A 106
VAL A 109
ASP A 141
LEU A 169
 None
 0.69A 6bq4A-1mjfA:
33.9		 6bq4A-1mjfA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 GLN A  30
GLY A  82
ILE A 105
ASP A 106
VAL A 109
ASP A 141
 None
 0.39A 6bq4B-1mjfA:
34.3		 6bq4B-1mjfA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  83
SER A  27
GLN A  30
ILE A 105
ASP A 141
 None
 1.23A 6bxnB-1mjfA:
3.1		 6bxnB-1mjfA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1mjf SPERMIDINE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  81
GLY A  82
GLY A  84
ILE A 105
ASP A 106
 None
 0.50A 6iftA-1mjfA:
10.1		 6iftA-1mjfA:
23.08