SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_F_5FWF1001_1 (SUPEROXIDE DISMUTASE [CU-ZN])	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	4 / 6	GLU A 93 LYS A 89 LYS A 98 GLU A 35	None	1.20A	4a7tF-1mjhA: 0.0	4a7tF-1mjhA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	5 / 11	ALA A 18 ASP A 13 SER A 141 LEU A 139 VAL A 156	ATP A2001 ( 3.7A) ATP A2001 (-3.4A) ATP A2001 (-2.6A) None None	1.38A	4kyaA-1mjhA: 3.2	4kyaA-1mjhA: 16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	5 / 10	ALA A 18 ASP A 13 SER A 141 LEU A 139 VAL A 156	ATP A2001 ( 3.7A) ATP A2001 (-3.4A) ATP A2001 (-2.6A) None None	1.36A	4kyaC-1mjhA: undetectable	4kyaC-1mjhA: 16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	5 / 11	ALA A 18 ASP A 13 SER A 141 LEU A 139 VAL A 156	ATP A2001 ( 3.7A) ATP A2001 (-3.4A) ATP A2001 (-2.6A) None None	1.34A	4kyaE-1mjhA: undetectable	4kyaE-1mjhA: 16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_G_FOLG703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	5 / 11	ALA A 18 ASP A 13 SER A 141 LEU A 139 VAL A 156	ATP A2001 ( 3.7A) ATP A2001 (-3.4A) ATP A2001 (-2.6A) None None	1.35A	4kyaG-1mjhA: 3.2	4kyaG-1mjhA: 16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_ACTA608_0 (SERUM ALBUMIN)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	3 / 3	LYS A 160 ARG A 159 HIS A 129	None	1.27A	4zbrA-1mjhA: 0.0	4zbrA-1mjhA: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KM9_B_ADNB201_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL)	1mjh	PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577) (Methanocaldococc us jannaschii)	5 / 12	ILE A 112 ILE A 124 LEU A 9 ALA A 18 VAL A 142	None None None ATP A2001 ( 3.7A) ATP A2001 (-3.5A)	1.21A	5km9B-1mjhA: undetectable	5km9B-1mjhA: 21.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A7T_F_5FWF1001_1","SUPEROXIDE DISMUTASE [CU-ZN]","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",4,"GLU A  93;LYS A  89;LYS A  98;GLU A  35","None","1.20A","4a7tF-1mjhA:0.0","4a7tF-1mjhA:23.23"],["4KYA_A_FOLA703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",5,"ALA A  18;ASP A  13;SER A 141;LEU A 139;VAL A 156","ATP A2001 ( 3.7A);ATP A2001 (-3.4A);ATP A2001 (-2.6A);None;None","1.38A","4kyaA-1mjhA:3.2","4kyaA-1mjhA:16.05"],["4KYA_C_FOLC703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",5,"ALA A  18;ASP A  13;SER A 141;LEU A 139;VAL A 156","ATP A2001 ( 3.7A);ATP A2001 (-3.4A);ATP A2001 (-2.6A);None;None","1.36A","4kyaC-1mjhA:undetectable","4kyaC-1mjhA:16.05"],["4KYA_E_FOLE703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",5,"ALA A  18;ASP A  13;SER A 141;LEU A 139;VAL A 156","ATP A2001 ( 3.7A);ATP A2001 (-3.4A);ATP A2001 (-2.6A);None;None","1.34A","4kyaE-1mjhA:undetectable","4kyaE-1mjhA:16.05"],["4KYA_G_FOLG703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",5,"ALA A  18;ASP A  13;SER A 141;LEU A 139;VAL A 156","ATP A2001 ( 3.7A);ATP A2001 (-3.4A);ATP A2001 (-2.6A);None;None","1.35A","4kyaG-1mjhA:3.2","4kyaG-1mjhA:16.05"],["4ZBR_A_ACTA608_0","SERUM ALBUMIN","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",3,"LYS A 160;ARG A 159;HIS A 129","None","1.27A","4zbrA-1mjhA:0.0","4zbrA-1mjhA:13.94"],["5KM9_B_ADNB201_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL","1mjh","PROTEIN (ATP-BINDING DOMAIN OF PROTEIN MJ0577)","Methanocaldococcus jannaschii",5,"ILE A 112;ILE A 124;LEU A   9;ALA A  18;VAL A 142","None;None;None;ATP A2001 ( 3.7A);ATP A2001 (-3.5A)","1.21A","5km9B-1mjhA:undetectable","5km9B-1mjhA:21.02"]]