SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		4 / 6 GLY A  64
TRP A 225
VAL A 287
ALA A 292
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
None
 0.14A 1p6kA-1mjtA:
45.4		 1p6kA-1mjtA:
36.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		4 / 8 LEU A  48
GLU A  45
ILE A 108
TYR A 217
 None
 1.13A 1qvtA-1mjtA:
1.0		 1qvtA-1mjtA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 TRP A  68
ARG A  65
PHE A 299
 None
 0.97A 1zeaH-1mjtA:
undetectable
1zeaL-1mjtA:
undetectable		 1zeaH-1mjtA:
21.94
1zeaL-1mjtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 12 GLY A 127
TYR A 240
ALA A 126
ASP A 156
ARG A 124
 None
 1.48A 2avdA-1mjtA:
undetectable		 2avdA-1mjtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		4 / 7 ARG A 234
ASP A 239
ASP A 238
TYR A 240
 NAD  A 700 (-3.2A)
None
None
None
 1.20A 2e5dA-1mjtA:
undetectable
2e5dB-1mjtA:
undetectable		 2e5dA-1mjtA:
22.77
2e5dB-1mjtA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		4 / 7 ASP A 238
TYR A 240
ARG A 234
ASP A 239
 None
None
NAD  A 700 (-3.2A)
None
 1.19A 2e5dA-1mjtA:
undetectable
2e5dB-1mjtA:
undetectable		 2e5dA-1mjtA:
22.77
2e5dB-1mjtA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 12 ASN A 272
VAL A 275
VAL A 233
TYR A 226
GLY A 232
 None
 1.35A 3medA-1mjtA:
undetectable
3medB-1mjtA:
undetectable		 3medA-1mjtA:
21.97
3medB-1mjtA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 GLY A  64
TRP A 225
VAL A 287
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
 0.13A 3n62B-1mjtA:
45.3		 3n62B-1mjtA:
36.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 GLY A  64
TRP A 225
VAL A 287
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
 0.15A 3n65B-1mjtA:
45.2		 3n65B-1mjtA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 GLY A  64
TRP A 225
VAL A 287
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
 0.11A 3n66B-1mjtA:
30.6		 3n66B-1mjtA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 12 ILE A  63
HIS A 289
ALA A 318
LEU A 317
PRO A 323
 None
 1.09A 3ozwB-1mjtA:
undetectable		 3ozwB-1mjtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 ARG A  57
ARG A  65
TRP A  68
 None
 1.42A 4cpzG-1mjtA:
undetectable		 4cpzG-1mjtA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 6 ARG A 124
GLU A 230
ARG A 234
ASP A 238
ARG A 241
 None
ITU  A 800 ( 3.0A)
NAD  A 700 (-3.2A)
None
None
 0.62A 4kcnA-1mjtA:
28.4		 4kcnA-1mjtA:
36.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 6 ARG A 124
GLU A 230
ARG A 234
ASP A 238
ARG A 241
 None
ITU  A 800 ( 3.0A)
NAD  A 700 (-3.2A)
None
None
 0.63A 4kcnB-1mjtA:
45.0		 4kcnB-1mjtA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		6 / 12 LEU A  28
ILE A  31
TYR A  41
ILE A 212
ILE A 215
PRO A 340
 None
 1.39A 4odrA-1mjtA:
undetectable
4odrB-1mjtA:
undetectable		 4odrA-1mjtA:
14.12
4odrB-1mjtA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 THR A 107
ASN A 119
PHE A 118
 None
 0.82A 4pd9A-1mjtA:
undetectable		 4pd9A-1mjtA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 GLY A  64
TRP A 225
VAL A 287
 HEM  A 500 ( 4.0A)
HEM  A 500 ( 3.4A)
None
 0.14A 5vuoB-1mjtA:
45.3		 5vuoB-1mjtA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		5 / 10 VAL A 284
GLY A 283
ALA A 201
LEU A 102
ASN A  98
 None
 1.15A 5x6yB-1mjtA:
undetectable		 5x6yB-1mjtA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG
(Staphylococcus
aureus) 		3 / 3 SER A 327
HIS A 331
TYR A 333
 None
SUC  A 601 ( 3.9A)
SUC  A 601 (-4.1A)
 0.83A 5y2tA-1mjtA:
0.4		 5y2tA-1mjtA:
undetectable