SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1mk2 SMAD 3
(Homo
sapiens) 		5 / 12 ILE A 395
GLY A 292
VAL A 256
SER A 310
TYR A 236
 None
 1.40A 1nbhA-1mk2A:
undetectable		 1nbhA-1mk2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 7 LEU A 239
THR A 391
PRO A 392
GLY A 380
 None
 0.97A 2ddwB-1mk2A:
undetectable		 2ddwB-1mk2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mk2 SMAD 3
(Homo
sapiens) 		3 / 3 LEU A 403
PRO A 402
LEU A 406
 None
 0.51A 2po5B-1mk2A:
undetectable		 2po5B-1mk2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mk2 SMAD 3
(Homo
sapiens) 		3 / 3 LEU A 403
PRO A 402
LEU A 406
 None
 0.53A 2po7B-1mk2A:
undetectable		 2po7B-1mk2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 7 MET A 373
ILE A 395
ASP A 257
SER A 263
 None
 1.14A 2xytI-1mk2A:
0.0		 2xytI-1mk2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 4 LEU A 403
PRO A 402
LEU A 406
ARG A 367
 None
None
None
ACY  A   1 (-3.6A)
 1.34A 3hcoB-1mk2A:
undetectable		 3hcoB-1mk2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1mk2 SMAD 3
(Homo
sapiens) 		3 / 3 LEU A 403
PRO A 402
LEU A 406
 None
 0.54A 3hcrA-1mk2A:
undetectable		 3hcrA-1mk2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 5 ILE A 341
LEU A 339
LYS A 340
ASN A 318
 None
 1.01A 4g19A-1mk2A:
0.0		 4g19A-1mk2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 4 ILE A 341
LEU A 339
LYS A 340
ASN A 318
 None
 1.02A 4g19D-1mk2A:
0.0		 4g19D-1mk2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1mk2 MADH-INTERACTING
PROTEIN
SMAD 3
(Homo
sapiens) 		4 / 6 ASP A 407
GLY A 401
PRO B 701
THR B 702
 None
 1.08A 4l1aB-1mk2A:
0.0		 4l1aB-1mk2A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 6 SER A 235
HIS A 398
ARG A 372
GLU A 396
 None
None
ACY  A   2 (-4.5A)
None
 1.23A 5x7pB-1mk2A:
undetectable		 5x7pB-1mk2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 6 SER A 235
HIS A 398
ARG A 372
GLU A 396
 None
None
ACY  A   2 (-4.5A)
None
 1.22A 5x7qA-1mk2A:
0.0		 5x7qA-1mk2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 6 SER A 235
HIS A 398
ARG A 372
GLU A 396
 None
None
ACY  A   2 (-4.5A)
None
 1.23A 5x7qB-1mk2A:
undetectable		 5x7qB-1mk2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 6 SER A 235
HIS A 398
ARG A 372
GLU A 396
 None
None
ACY  A   2 (-4.5A)
None
 1.19A 5x7rA-1mk2A:
undetectable		 5x7rA-1mk2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1mk2 SMAD 3
(Homo
sapiens) 		4 / 6 SER A 235
HIS A 398
ARG A 372
GLU A 396
 None
None
ACY  A   2 (-4.5A)
None
 1.19A 5x7rB-1mk2A:
0.0		 5x7rB-1mk2A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1mk2 SMAD 3
(Homo
sapiens) 		3 / 3 ASN A 344
PRO A 402
GLN A 404
 None
 0.87A 6jnhA-1mk2A:
0.0		 6jnhA-1mk2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1mk2 SMAD 3
(Homo
sapiens) 		3 / 3 ASN A 344
PRO A 402
GLN A 404
 None
 0.90A 6jogA-1mk2A:
undetectable		 6jogA-1mk2A:
20.18