SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1mk3 APOPTOSIS REGULATOR
BCL-W
(Homo
sapiens) 		4 / 8 ALA A  97
VAL A 100
LEU A  63
THR A  59
 None
 0.87A 2it4A-1mk3A:
undetectable		 2it4A-1mk3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1mk3 APOPTOSIS REGULATOR
BCL-W
(Homo
sapiens) 		4 / 8 LEU A  12
VAL A 126
LEU A 129
GLY A 142
 None
 0.81A 4r3aA-1mk3A:
undetectable		 4r3aA-1mk3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1mk3 APOPTOSIS REGULATOR
BCL-W
(Homo
sapiens) 		4 / 8 GLY A  33
ARG A  46
GLN A  23
TYR A  19
 None
 0.84A 5vlmB-1mk3A:
0.1		 5vlmB-1mk3A:
25.70