SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1mk7 TALIN
(Gallus
gallus) 		3 / 3 LYS B 343
ILE B 348
THR B 307
 None
 0.67A 1rx3A-1mk7B:
undetectable		 1rx3A-1mk7B:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 7 SER B 379
ALA B 360
SER B 365
THR B 367
 None
 0.58A 3cfqA-1mk7B:
undetectable
3cfqB-1mk7B:
undetectable		 3cfqA-1mk7B:
22.00
3cfqB-1mk7B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1mk7 TALIN
(Gallus
gallus) 		4 / 7 TYR B 241
GLU B 293
LEU B 301
LYS B 234
 None
 1.38A 3k8mB-1mk7B:
undetectable		 3k8mB-1mk7B:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1mk7 TALIN
(Gallus
gallus) 		4 / 6 ILE B 396
LEU B 353
ARG B 358
THR B 367
 None
 1.12A 3wg7A-1mk7B:
undetectable
3wg7J-1mk7B:
0.0		 3wg7A-1mk7B:
15.13
3wg7J-1mk7B:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1mk7 TALIN
(Gallus
gallus) 		3 / 3 LYS B 343
ILE B 348
THR B 307
 None
 0.68A 4gh8A-1mk7B:
undetectable		 4gh8A-1mk7B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 7 ALA B 360
SER B 365
THR B 367
SER B 379
 None
 0.41A 4ikjA-1mk7B:
undetectable
4ikjB-1mk7B:
undetectable		 4ikjA-1mk7B:
22.49
4ikjB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 8 SER B 379
ALA B 360
SER B 365
THR B 367
 None
 0.37A 4ikjA-1mk7B:
undetectable
4ikjB-1mk7B:
undetectable		 4ikjA-1mk7B:
22.49
4ikjB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 8 ALA B 360
SER B 365
THR B 367
SER B 379
 None
 0.43A 4ikkA-1mk7B:
undetectable
4ikkB-1mk7B:
undetectable		 4ikkA-1mk7B:
22.49
4ikkB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 7 SER B 379
ALA B 360
SER B 365
THR B 367
 None
 0.45A 4ikkA-1mk7B:
undetectable
4ikkB-1mk7B:
undetectable		 4ikkA-1mk7B:
22.49
4ikkB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 7 ALA B 360
SER B 365
THR B 367
SER B 379
 None
 0.46A 4iklA-1mk7B:
undetectable
4iklB-1mk7B:
undetectable		 4iklA-1mk7B:
22.49
4iklB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1mk7 TALIN
(Gallus
gallus) 		4 / 8 SER B 379
ALA B 360
SER B 365
THR B 367
 None
 0.44A 4iklA-1mk7B:
undetectable
4iklB-1mk7B:
undetectable		 4iklA-1mk7B:
22.49
4iklB-1mk7B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1mk7 TALIN
(Gallus
gallus) 		5 / 8 ILE B 348
VAL B 347
ILE B 392
ILE B 399
ILE B 356
 None
 1.44A 5hi2A-1mk7B:
undetectable		 5hi2A-1mk7B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1mk7 TALIN
(Gallus
gallus) 		3 / 3 CYH B 286
LYS B 284
HIS B 250
 None
 1.20A 5js5A-1mk7B:
1.3		 5js5A-1mk7B:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1mk7 TALIN
(Gallus
gallus) 		4 / 4 LEU B 260
ARG B 277
ILE B 279
PHE B 280
 None
 1.06A 5kirB-1mk7B:
undetectable		 5kirB-1mk7B:
14.93