SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1mkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE
(Escherichia
coli) 		4 / 7 THR A 125
TYR A 155
ARG A 127
MET A  86
 None
 1.46A 3wipF-1mkbA:
0.0
3wipG-1mkbA:
0.0		 3wipF-1mkbA:
19.63
3wipG-1mkbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE
(Escherichia
coli) 		4 / 5 LEU A  28
ALA A  85
VAL A  54
ILE A 128
 None
 0.95A 4xe3B-1mkbA:
undetectable		 4xe3B-1mkbA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE
(Escherichia
coli) 		3 / 3 LEU A  64
ILE A  60
TYR A 126
 None
 0.65A 5uunB-1mkbA:
undetectable		 5uunB-1mkbA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE
(Escherichia
coli) 		5 / 11 SER A  15
GLY A  91
LEU A 160
VAL A 162
ASP A 144
 None
 1.26A 6i5zD-1mkbA:
undetectable		 6i5zD-1mkbA:
19.35